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Antitumor activity of a new platinum complex, (R)-(-)-2-aminomethylpyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II), against cisdiamminedichloroplatinum (II)-resistant murine leukemia cell line


, : Antitumor activity of a new platinum complex, (R)-(-)-2-aminomethylpyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II), against cisdiamminedichloroplatinum (II)-resistant murine leukemia cell line. Gan to Kagaku Ryoho. Cancer & ChemoTherapy 17(1): 73-78

Antitumor activity of a new platinum complex, (R)-(-)-2-aminomethylpyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II) (DWA 2114 R) against cisdiamminedichloroplatinum (II) (CDDP)-resistant tumor was examined in in vitro and in vivo experiments. CDDP-resistant line was established from L 1210 mouse leukemia cells by continuous exposure to CDDP in dose-escalation manner. Six clones were isolated from parental resistant line and one of these clones, clone f, which was found to be highly resistant (30-40 fold) to CDDP, was used in the following experiments. Clone f showed 4-7 fold cross-resistance to DWA 2114 R and 11-19 fold to cisdiammine-1, 1-cyclobutanedicarboxylatoplatinum (II) (CBDCA) in in vitro growth inhibition assay. DWA 2114 R showed the most effective antitumor activity against mice transplanted with the resistant cells in the increase of life span (ILS%). About 100% of ILS and cured mice were observed in the treatment with DWA 2114 R. On the other hand, CDDP or CBDCA showed a little increase in the survival time (less than 40% of ILS) and all mice died. These results suggest that DWA 2114 R seemed to be more effective against CDDP-resistant tumors clinically than CDDP and CBDCA.

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PMID: 2404458


Other references

Beilina, S.I.; Zinchenko, V.P.; Matveeva, N.B.; Teplov, V.A., 1996: The dependence of contractile activity autooscillation on oxidation-reduction state in Physarum polycephalum plasmodium. Physarum plasmodium contractile oscillations suppressed by respiratory inhibitors was shown to be reestablished under alpha-ketoglutarate-stimulated glutamate-dehydrogenase activation. Measurements of NADH-fluorescence in the microplasmodial suspe...

Goethe, F., 1934: Die Weidenmeise im Teutoburger Wald. Ein Beitrag zur Tierwelt des Naturschutzgebietes D'onoperteich.. Abhandlungen aus dem Westfaelischen Provinzial-Museum Munster I W: 5: 3-16

Tiddens, H.A.; Geller, D.E.; Challoner, P.; Speirs, R.J.; Kesser, K.C.; Overbeek, S.E.; Humble, D.; Shrewsbury, S.B.; Standaert, T.A., 2007: Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and older. Several inhaled drugs for use by cystic fibrosis (CF) patients are formulated for nebulizer use only. This therapy is time consuming and includes the risk of contamination of the nebulizers. Dry powder inhalers (DPI) can be an attractive alternati...

Ento, K.; Araya, K.; Kon, M., 2003: The life history and colony composition of Cylindrocaulus patalis (Coleoptera: Passalidae). The life history and colony composition of Cylindrocaulus patalis (Lewis, 1883) was investigated in Miyazaki Prefecture, Kyushu, southwest Japan, from May 2001 to October 2002. Cylindrocaulus patalis lives in family groups in galleries excavated i...

Lofgren, S., 1957: Diagnosis and incidence of sarcoidosis. British Journal of Tuberculosis and Diseases of the Chest 51(1): 8-13

Cabot, D., 1966: The status and distribution of the Barnacle goose (Branta leucopsis) in Ireland, March, 1966. Publications Irish Wildfowl Conservancy, 3: 1-2

Anonymous, 1901: Prize-Subjects In Applied Science. Science 14(350): 420-421

Verheyen, R., 1956: Les longueurs de l'aileron et de la queue en relation avec l'age des oiseaux. Gerfaut, 46: 65-74

Morgan E.T.; Koop D.R.; Coon M.J., 1983: Comparison of 6 rabbit liver cytochrome p 450 isozymes in formation of a reactive metabolite of acetaminophen. An ethanol-inducible form of rabbit liver microsomal cytochrome P-450, designated isozyme 3a was isolated. Since the hepatotoxicity of acetaminophen is increased in ethanol-treated animals and the human alcoholic, the activity of the 6 available P...

Kim JongKyong; Twede, D.; Lichty, J., 1997: Consumer attitudes about open dating techniques for packaged foods and over-the-counter drugs. This study based on a 1995 survey of 200 shoppers in Michigan, reveals the following consumer attitudes about open dating techniques for packaged foods and OTC (over-the-counter) drugs. 1. An open date is a very important piece of information, esp...