geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Articular and muscular hemorrhages in hemophilia A with anti-factor VIII antibodies. Treatment with selected batches of PPSB (factor IX concentrate)


, : Articular and muscular hemorrhages in hemophilia A with anti-factor VIII antibodies. Treatment with selected batches of PPSB (factor IX concentrate). Presse Medicale 14(19): 1073-1076

Over a 10-month period, 65 bleeding episodes in 14 hemophilia A patients with anti-Factor VIII antibodies were treated with a non-activated Factor IX concentrate (PPSB). A single dose of 58-102 U/kg of Factor IX (average 80 U/kg) was used in 51 hemarthroses, 13 muscle hematomas and one dental bleed. Overall clinical results were satisfactory in 51% of cases. Forty nine per cent of acute hemarthroses were clinically improved. Safety tests were unchanged and no significant elevation of anti-VIII: C titers was recorded. These preliminary results ae similar to those obtained with single doses of activated prothrombin complex concentrates given to the same patients (Autoplex and FEIBA).

US$29.90

PMID: 3158962


Other references

Liu, J.; Guo, W.; Tong, M., 2016: Intraoperative indocyanine green fluorescence guidance for excision of nonpalpable breast cancer. Different techniques have been used for the guidance of nonpalpable breast cancer (NBC), but none of them has yet achieved perfect results. The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescence-guided nonpal...

Boadu, F.O., 1981: Econometric analysis of demand and supply of fertilizer in the United States. Those variables that influence the demand for and supply of fertilizer in the USA are identified and quantified. Demand equations were estimated for the nine agricultural regions of the US and for the US as a whole. Simultaneous demand and supply...

Wain, R.L.; Wilkinson, E.H., 1945: Studies upon the copper fungicides. VIII The penetration of copper into germinating Peas. In further studies on the copper fungicides it was found that pea seeds of the varieties Foremost, Surprise, and Eclipse, while swelling in water, exuded substances which were capable of dissolving insoluble copper seed dressings whether on the se...

Hernández-Pinzón, I.; Cifuentes, M.; Hénaff, E.; Santiago, Néstor.; Espinás, M.Lluïsa.; Casacuberta, J.M., 2012: The Tnt1 retrotransposon escapes silencing in tobacco, its natural host. Retrotransposons' high capacity for mutagenesis is a threat that genomes need to control tightly. Transcriptional gene silencing is a general and highly effective control of retrotransposon expression. Yet, some retrotransposons manage to tra...

Mulcahy, M.T., 1983: The hazards of tap water. Prenatal Diagnosis 3(1): 81-81

Hu, H.; Kolesnikov, A.; Riggs, J.R.; Wesson, K.E.; Stephens, R.; Leahy, E.M.; Shrader, W.D.; Sprengeler, P.A.; Green, M.J.; Sanford, E.; Nguyen, M.; Gjerstad, E.; Cabuslay, R.; Young, W.B., 2006: Potent 4-amino-5-azaindole factor VIIa inhibitors. The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT. (c) 2006 Elsevier Ltd. All rights reserved.

Hoskins, GE.; West, CJ.; Kling, AE., 1984: Traitement informatique des problemes de pathologie du poisson dans les piscifactures. Canadian Special Publication of Fisheries and Aquatic Sciences, 68: 1-46

Schmidt, G.D.; Martin, R.L., 1978: Tapeworms of the Chaco Boreal, Paraguay, with two new species. Mathevotaenia paraguayae n.sp. from the small intestine of Euphractus sexcinctus in Paraguay differs from M. didelphidis in having a transverse cirrus pouch anterior to the vagina. Monoecocestus mackiewiczi n.sp. from the small intestine of Phyllo...

Inamochi H.; Shiba R., 1983: Optimum design of the bone. The shape of the bone will adapt to the surrounding mechanical conditions. This concept, described as Wolff's law, is widely accepted by many orthopedic surgeons. Because it is too abstract, it hasn't been applied to the clinical cases....

Wang, X.; Wang, F.; Sy, M-Sun.; Ma, J., 2004: Calpain and other cytosolic proteases can contribute to the degradation of retro-translocated prion protein in the cytosol. PrP, a cell surface-localized N-linked glycoprotein, is required for the pathogenesis of prion diseases. Recent studies have revealed that prion protein (PrP) becomes neurotoxic and prone to aggregation when it is in the cytosol, suggesting that c...