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Calcineurin trapped in liposomes inhibits the action potentials of isolated 3-days-old embryonic chick ventricle


, : Calcineurin trapped in liposomes inhibits the action potentials of isolated 3-days-old embryonic chick ventricle. Journal of Developmental Physiology 18(3): 121-124

Calcineurin, an intracellular protein phosphatase (type 2B), is reported to inhibit L-type (slow) calcium channels and thereby play a key role in channel inactivation. The present study was undertaken to examine effects of calcineurin on slow channel dependent action potentials of 3-days-old embryonic chick ventricle and to assess the role of this enzyme in regulation of developing slow channels. Calcineurin trapped in phosphatidylcholine-liposomes to facilitate its intracellular uptake was found to inhibit maximal upstroke velocity (+Vmax), overshoot and duration of action potentials. At higher doses of calcineurin containing liposomes the preparations ceased to exhibit spontaneous activity but elicited electrically driven action potentials with lower +Vmax and overshoot. These observations show that calcineurin down-modulates the embryonic cardiac slow channels under basal conditions.

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PMID: 1338732


Other references

Cecchin, E.; D.M.rchi, S.; Falleti, E.; Adorati, M.; Sepiacci, G.; Spulzaro, P.; Zanello, F.; Gonano, F.; Bartoli, E., 1998: Lipoprotein is an independent predictor of mortality from atherothrombotic vascular events in hemodialysis patients A 5-year prospective study. Nephrology Dialysis Transplantation 13(6): A201, June

Finnegan, J.R.; Meischke, H.; Zapka, J.G.; Leviton, L.; Meshack, A.; Benjamin-Garner, R.; Estabrook, B.; Hall, N.J.; Schaeffer, S.; Smith, C.; Weitzman, E.R.; Raczynski, J.; Stone, E., 2000: Patient delay in seeking care for heart attack symptoms: findings from focus groups conducted in five U.S. regions. Background: Patient delay in seeking health care for heart attack symptoms is a continuuing problem in the United States. Methods: Investigators conducted focus groups (N = 34; 207 participants) in major U.S. regions (NE, NW, SE, SW, MW) as format...

Krieger Brauer H.I.; Gratzl M., 1983: Effects of monovalent and divalent cations on calcium fluxes across chromaffin secretory membrane vesicles. Bovine chromaffin secretory vesicle ghosts loaded with Na+ were found to take up Ca2+ when incubated in K+ media or in sucrose media containing micromolar concentrations of free Ca2+. Li+- or choline+-loaded ghosts did not take up Ca2+. The Ca2+ a...

Magnussen, H.; Reuss, G.; Jörres, R.; Kessler, K., 1983: Protective effect of disodium cromoglycinic acid (DSCG) on inhalative thermal provocation in bronchial asthma. Praxis und Klinik der Pneumologie 37(9): 364-371

Gale, E.; Prince, V.; Lumsden, A.; Clarke, J.; Holder, N.; Maden, M., 1996: Late effects of retinoic acid on neural crest and aspects of rhombomere. We exposed st.10 chicks to retinoic acid (RA), both globally, and locally to individual rhombomeres, to look at its role in specification of various aspects of hindbrain derived morphology. Previous studies have looked at RA exposure at earlier st...

Yamakawa, M., 1983: New media in the era of information revolution (6). From vacuum tubes to transistors. Kurinikaru Sutadi 4(12): 1516-1519

Lennie, T.A.; Chung, M.L.; Habash, D.L.; Moser, D.K., 2005: Dietary fat intake and proinflammatory cytokine levels in patients with heart failure. Dietary fat intake affects proinflammatory cytokine levels of healthy adults. Whether dietary fats have similar effects in patients with heart failure (HF) is unknown. The purposes of this study were to determine (1) effect of dietary fat on inter...

Narayan, S.K.; Firbank, M.J.; Saxby, B.K.; Stansby, G.; Hansrani, M.; O'Brien, J.T.; Ford, G.A., 2011: Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension. We determined using serial MR imaging whether raised plasma homocysteine levels are associated with increased brain atrophy, white matter lesion (WML) progression or incidence of silent brain infarcts (SBIs) in older hypertensive subjects. Brain a...

Nikitishin, P.K.; Gvozdev, I.M.; Voronchuk, M.S.; Lutskevich, V.L., 1976: Novarsenol in pneumonia in piglets. Veterinariia: 92-94

Vaughan, T.W., 1933: The Biogeographic Relations of the Orbitoid Foraminifera. A comprehensive consideration of the paleogeographic distr. of the orbitoid Foraminifera and its significance, based on a study of the orbitoids themselves, their ecology and geologic range with the possibilities of their wide distr. by means of o...