+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cardiopulmonary bypass after cardiac arrest and prolonged closed-chest CPR in dogs

, : Cardiopulmonary bypass after cardiac arrest and prolonged closed-chest CPR in dogs. Annals of Emergency Medicine 16(6): 620-627

We studied a clinically realistic field-to-hospital scenario in dogs with four-minute ventricular fibrillation (VF) cardiac arrest followed by 30-minute standard external CPR basic life support (BLS). At the end of this 34-minute insult, cardiopulmonary bypass (CPB) was used for early defibrillation and assisted circulation for one hour (n = 10). Recovery was compared with that of control dogs (n = 10) in which standard CPR with advanced life support (ALS) for another 30 minutes was used for restoration of spontaneous circulation (ROSC). Both groups had hemodilution and heparinization; controlled blood pressure, blood gases, ventilation, and other parameters for 20 hours; and intensive care to 72 hours. During CPR-BLS of 30 minutes in both groups signs of cerebral viability returned. CPB achieved ROSC more successfully (ten of ten vs five of ten CPR-ALS controls) (P less than .02); and more rapidly, with less defibrillation energy (first countershock in eight of ten) and with less epinephrine (P less than .01). CPB improved 72-hour survival (seven of ten vs three of ten controls) (P less than .05). Between two and 24 hours, of those with ROSC, cardiac complications killed three of ten CPB dogs (after weaning), and two of five CPR-ALS dogs (NS). All seven CPB survivors to 72 hours were neurologically normal; of the three CPR-ALS survivors, one remained with severe neurologic deficit and two were neurologically normal (seven of ten CPB vs two of ten controls, P = .025). Starting CPR-BLS within four minutes of arrest can maintain cerebral viability.


PMID: 3578964

Other references

Malaisse W.; Malaisse Lagae F., 1970: Biochemical pharmacological and physiological aspects of the adenyl cyclase phospho di esterase system in the pancreatic beta cells. Falkmer, S , B Hellman And I -B Taljedal (Edited By) Wenner-Gren Center International Symposium Series, Vol 16 The Structure And Metabolism Of The Pancreatic Islets Xii + 568p Illus Pergamon Press Inc : Elmsford, N Y , U S A , Oxford, England 435-444

Kracke, F.; Virdis, B.; Bernhardt, P.V.; Rabaey, K.; Krömer, J.O., 2016: Redox dependent metabolic shift in iClostridium autoethanogenum by extracellular electron supply. Microbial electrosynthesis is a novel approach that aims at shifting the cellular metabolism towards electron-dense target products by extracellular electron supply. Many organisms including several acetogenic bacteria have been shown to be able t...

van Wijmen, M.P.S.; Pasman, H.Roeline.W.; Widdershoven, G.A.M.; Onwuteaka-Philipsen, B.D., 2015: Motivations, aims and communication around advance directives: a mixed-methods study into the perspective of their owners and the influence of a current illness. What are motivations of owners of an advance directive (AD) to draft an AD, what do they aim for with their AD and do they communicate about their AD? Written questionnaires were sent to a cohort of people owning different types of ADs (n=5768). A...

Sutter, G.R.; Branson, T.F.; Fisher, J.R.; Elliott, N.C., 1991: Effect of insecticides on survival, development, fecundity, and sex ratio in controlled infestations of western corn rootworm (Coleoptera: Chrysomelidae). In a 4-yr study, granular soil insecticides were applied at planting time to plots of maize, Zea mays L., infested with population densities of eggs of western corn rootworms, Diabrotica virgifera virgifera LeConte, to determine how insecticides a...

Cowen, E., 1969: Who provides--and who pays?. Nursing Mirror and Midwives Journal 128(5): 34-35

López, S.I.; Ciocca, M.; Oleastro, Mías.; Cuarterolo, M.L.; Rocca, A.; de Dávila, Mía.T.G.; Roy, A.; Fernández, Mía.C.; Nievas, E.; Bosaleh, A.; Torgerson, T.R.; Ruiz, Jé.A., 2012: Autoimmune hepatitis type 2 in a child with IPEX syndrome. Journal of Pediatric Gastroenterology and Nutrition 53(6): 690-693

Richter, G.; Neymeyer, H.G.; Gründel, A.; Richter, G.; Kemper, A.; Wachs, A., 1988: The value of laboratory markers in the diagnosis of alcoholism. Psychiatrie, Neurologie und Medizinische Psychologie. Beihefte 39: 93-95

Ishiura, M.; Okada, Y., 1979: The role of actin in temperature-dependent gel-sol transformation of extracts of Ehrlich ascites tumor cells. Ehrlich ascites tumor cell extracts form a gel when warmed to 25 degrees C at pH 7.0 in sucrose solution, and the gel rapidly becomes a sol when cooled to 0 degrees C. This gel-sol transformation was studied quantitatively by determining the volum...

Gallwas, J.; Stanchi, A.; Ditsch, N.; Schwarz, T.; Dannecker, C.; Mueller, S.; Stepp, H.; Mortensen, U., 2015: Effect of optical clearing agents on optical coherence tomography images of cervical epithelium. Optical coherence tomography (OCT) can be used as an adjunct to colposcopy in order to detect precancerous and cancerous cervical lesions. Optical clearing agents (OCAs) temporarily reduce the optical scattering of biological tissues. The purpose...

Wegorek, W., 1972: Crrrent achievements and trends in development of plant protection. O Stanie Badan Naukowych w Rolnictwie: 0-100