geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chromosomal aberrations in muntjac cells resulting from exposure to interferon


, : Chromosomal aberrations in muntjac cells resulting from exposure to interferon. Journal of Interferon Research 5(2): 257-264

Cells of the Indian deer (Muntiacus muntjac) are sensitive to the antiviral and antiproliferative action of human beta-interferon (beta-IFN). Because of their low diploid chromosome number and readily identifiable chromosomes, they provide a convenient model system in which to test for the ability of IFN treatment to result in chromosome abnormalities. Increases in the frequencies of chromosome gaps and breaks have been observed after 72 h of treatment with IFN at a concentration of 100 U/ml. At IFN concentrations of 10-100 U/ml, there is a higher proportion of aberrations in the X chromosome than would be expected in a random distribution. At 1,000-1,700 U/ml IFN, there is an increase in the proportion of cells with multiple abnormalities over that observed at 0-100 U/ml IFN, and the distribution of aberrations appears to be random.

US$29.90

PMID: 4040146


Other references

Pettay O., 1982: Septicemia in new borns and infants. Scandinavian Journal of Infectious Diseases Supplementum (31): 105-111

Arbuthnott, G.W.; Ingham, C.A.; Wickens, J.R., 2000: Dopamine and synaptic plasticity in the neostriatum. After the unilateral destruction of the dopamine input to the neostriatum there are enduring changes in rat behaviour. These have been ascribed to the loss of dopamine and the animals are often referred to as 'hemiparkinsonian'. In the d...

Swearingen, C.A.; Chambers, M.G.; Lin, C.; Marimuthu, J.; Rito, C.J.; Carter, Q.L.; Dotzlaf, J.; Liu, C.; Chandrasekhar, S.; Duffin, K.L.; Mitchell, P.G.; Durham, T.B.; Wiley, M.R.; Thirunavukkarasu, K., 2011: A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. To develop a short-term in vivo model in rats, with an enzyme-linked immunosorbent assay (ELISA) readout for specific aggrecanase-cleaved aggrecan fragments, to facilitate testing of aggrecanase inhibitors. Monosodium iodoacetate (MIA), a metaboli...

Zhang, J.; Matsushita, M.M.; Kong, X.X.; Abe, J.; Iyoda, T., 2001: Photoresponsive coordination assembly with a versatile logs-stacking channel structure based on redox-active ligand and cupric ion. Journal of the American Chemical Society 123(48): 12105-6

Souza, J.; Molfetta, Fábio.A.; Honório, Káthia.M.; Santos, R.H.A.; da Silva, Aérico.B.F., 2004: A study on the antipicornavirus activity of flavonoid compounds (flavones) by using quantum chemical and chemometric methods. The AM1 semiempirical method is employed to calculate a set of molecular properties (variables) of 45 flavone compounds with antipicornavirus activity, and 9 new flavone molecules are used for an activity prediction study. Principal Component Anal...

Bykov, M.D.; Shevchenko, V.M., 1981: Promising irrigation systems for intensive orchards in the Ukraine. Stationary installation allowed maximum mechanization and automation of orchard irrigation but did not inconvenience other work and led to rational water use. The highest yields of apple cv. Renet Simirenko were obtained with drip irrigation (24 t...

Pigg K.B.; Taylor T.N., 1984: Cormose lycopod bases from mazon creek illinois usa and the phylogeny of the lycopods. Ohio Journal of Science 84(2): 7

Palm, C.; Jayamanne, M.; Kjellander, M.; Hällbrink, M., 2007: Peptide degradation is a critical determinant for cell-penetrating peptide uptake. Cell-penetrating peptide mediated uptake of labels appears to follow an equilibrium-like process. However, this assumption is only valid if the peptides are stabile. Hence, in this study we investigate intracellular and extracellular peptide degr...

Murphy, J.R., 1988: Diphtheria-related peptide hormone gene fusions: a molecular genetic approach to chimeric toxin development. There has been considerable effort in chemically conjugating a variety of plant and bacterial toxins to monoclonal antibodies that are directed to surface antigens on target cells. Coupling has been mediated through disulfide linkage, and the resu...

Altan, E.; Aydin, K.; Erkocak, O.; Senaran, H.; Ugras, S., 2015: The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty. This study investigated the efficacy of platelet-rich plasma (PRP) on articular surfaces on which the mosaicplasty technique was performed. Our hypothesis was that PRP can accelerate the osseointegration process and enhance the quality of articula...