geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin


, : Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin. Arzneimittel-Forschung 40(10): 1076-1078

The in-vivo metabolic conversion of equal mixture of phenytoin and decadeuteriophenytoin to the para-hydroxy metabolite in rat was investigated in order to verify a possible role of an insertion or abstraction mechanisms in the hydroxylation process. Determination of kH/k2H values of urine samples at 2 h intervals for 24 h indicated that there was no isotope effect during in-vivo para-hydroxylation of phenytoin. This gives evidence of the arene oxide intermediacy possibly being the sole pathway for para-hydroxylation of phenytoin.

US$29.90

PMID: 2291743


Other references

Levy, J.; Hartmann, J.L., K.; An, Y.A.gary, A., 2007: Multi-Criteria Decision Support Systems for Flood Hazard Mitigation and Emergency Response in Urban Watersheds. Flood management problems are inherently complex, time-bound and multi-faceted, involving many decision makers (with conflicting priorities and dynamic preferences), high decision stakes, limited technical information (both in terms of quality and...

A. Öktener, A.Alas, K.Solak, 2009: Occurence of Diplectanum aequans (Wagener,1857) on the cultured sea bass, Dicentrarchus labrax (Linnaeus, 1758) from the Black Sea of Turkey. This report of Diplectanum aequans (Wagener,1857) (Platyhelminthes, Diplectanidae) was presented for the first time from the gills of Dicentrarchus labrax (Linnaeus, 1758) (Perciformes, Moronidae) cultured in the Black Sea of Turkey (Vona Koyu, Or...

Dobricki, M.; de la Rosa, S., 2015: The structure of conscious bodily self-perception during full-body illusions. Previous research suggests that bodily self-identification, bodily self-localization, agency, and the sense of being present in space are critical aspects of conscious full-body self-perception. However, none of the existing studies have investiga...

Drobysheva, N.I., 2000: The effect of fertilizers on nodule formation and yield of soya. Data are presented of the effects of different rates of N, P, and K fertilizers on nodule formation and yield of soyabeans in an experiment on a leached chernozem in Siberia, Russia, from 1993 to 1998. During the sowing of soyabeans a preparation...

Drescher, J., 1957: Depot vaccines. II. Method for estimation of virus content in exstirpated deposits of PR-8-influenza virus-gamma-aluminum oxide vaccines. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-Hygienische Bakteriologie, Virusforschung und Parasitologie. Originale 168(3-4): 181-193

Hagihara, M.; Kashiwase, H.; Katsube, T.; Kimura, T.; Komai, T.; Momota, K.; Ohmine, T.; Nishigaki, T.; Kimura, S.; Shimada, K., 1999: Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents. Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the c...

Sun, K.; Guan, G.; Jin, C.; Liu, Y.; Zhang, D.; Hao, Y.; Lou, W.; Shi, P.; Sun, L., 2012: Tympanoplasty with soft-wall reconstruction of ear canal. To observe the therapeutic effect of tympanoplasty with soft-wall reconstruction of ear canal for chronic otitis media with cholesteatoma. Seventy-three patients (76 ears) suffering from chronic otitis media with cholesteatoma were treated with ca...

Peinemann, F.; Sauerland, S., 2015: Effectiveness of negative pressure wound therapy is still unproven. Journal of Wound Care 20(2): 88, Author Reply 88-9

Krogstad O.; Dahl B.L., 1985: Dento facial morphology in patients with advanced attrition. Dento-facial morphology was studied in a group of 20 adults of Norwegian ancestry with pathological attrition of the incisors. The mandible was more horizontal, the gonial angle more acute and the interincisal angle more obtuse than in a normal ad...

Mclean, D.M., 1977: Polio myelitis resurfaced. Following the recovery of potentially virulent poliovirus in sewage effluent in Canada, a plea is made to close the gaps in the nationwide immunization program through the extensive use of Sabin vaccine.