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Comparison of local anesthetic activities between cis and trans isomers of DL-1-benzoyloxy-2-dimethylamino-1,2,3,4-tetrahydronaphthalene


, : Comparison of local anesthetic activities between cis and trans isomers of DL-1-benzoyloxy-2-dimethylamino-1,2,3,4-tetrahydronaphthalene. Japanese Journal of Pharmacology: 13-19

The local anesthetic activities of cis- and trans- dl-1-benzoyloxy-2-dimethylamino-1,2,3,4-tetrahydronaphthalene were compared using several methods with guinea-pigs. The cis compound (YAU-17) was 2.9 to 6 times as potent as its trans isomer and exceeded procaine, lidocaine and cocaine in potencies of corneal anesthesia, intracutaneous anesthesia and sciatic nerve block. In another experiment on isolated frog sartorius muscle, all of the local anesthetics suppressed the twitch contractions elicited by stimulation of the sciatic nerve. The neuromuscular blocking activity of the cis compound was more pronounced than that of the trans form. Supersensitivity to noradrenaline was produced by both of the stereoisomers in isolated vas deferens of guinea-pigs although there was no difference in the activity. The sensitizing action was also demonstrable with cocaine and lidocaine but not with procaine. When injected intravenously into mice, the cis compound was twice as toxic as its isomer. It is postulated that stereoselectivity is to some extent involved in the mechanisms of action of the local anesthetic agents.

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PMID: 1263353


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Atanassova, B.; Shtereva, L.; Georgieva, Y.; Balatcheva, E., 2004: Study on seed coat morphology and histochemistry in three anthocyanin-less mutants in tomato (Lycopersicon esculentum Mill.) in relation to their enhanced germination. The morphology and histochemistry of seed coat in 3 tomato mutants, i.e. anthocyaninless of Hoffmann (ah), anthocyanin without (aw) and baby lea syndrome (bls), were studied in relation to their enhanced germination observed under optimum and stre...

Inamura, T., 1992: Tolerable growth level of Eleocharis kuroguwai Ohwi in rice fields. The relationship between the reduction of rice yield and the quantity of E. kuroguwai to which various amounts of herbicides were applied was studied in field trials over 3 years. Reductions in ear numbers, 1000-kernel wt and percentage of ripened...

Allman, G.J., 1870: The genetic succession of Zooids in the Hydroidea. Transactions of the Royal Society of Edinburgh, xxvi(pt. 1: 97-106

Matsuyama, H.; Miyaoka, K.; Masuda, K., 2005: Year-to-year variations of the stable isotopes in precipitation in February at Cuiaba, located on the northern fringe of Pantanal, Brazil. Large year-to-year variations of delta 18O were found in the precipitation recorded in the International Atomic Energy Agency/Global Network of Isotopes in Precipitation (IAEA/GNIP) database for February at Cuiaba, located on the northern fringe o...

Macgregor I.M., 1983: Preliminary results on the relationship of coal petrology to coal cuttability in some South Africa coals. Special Publication - Geological Society of South Africa 7: 117-128

Mazur, W.; Toljamo, T.; Ohlmeier, S.; Vuopala, K.; Nieminen, P.; Kobayashi, H.; Kinnula, V.L., 2011: Elevation of surfactant protein A in plasma and sputum in cigarette smokers. Serum surfactant protein (SP)-A has been postulated to associate with pulmonary fibrosis, but its role in cigarette smoking-related lung diseases is undefined. SP-A levels in plasma and induced sputum in nonsmokers, smokers with respiratory sympto...

Matti, B.A.; Nicolle, F.V., 1989: A simple technique for removing a silastic gel-filled breast implant through the axillary approach. We present a simple, atraumatic technique for removing a breast implant through a small incision following transaxillary breast augmentation, using straight artery forceps with jaws covered with a length of soft rubber catheter. This provides a ge...

Thélot, B., 2011: Epidemiology of the home and leisure injuries among children. Archives de Pediatrie 17(6): 704-705

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Chalnot, P.; Grosdidier, J.; Hirtzmann, C., 1953: Diagnostic and therapeutic problem of acute hemorrhagic pancreatitis. Revue Medicale de Nancy 78: 653-655