+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Complementation analysis of ataxia-telangiectasia

, : Complementation analysis of ataxia-telangiectasia. Kroc Foundation Series 19: 147-162

In a number of laboratories genetic analysis of ataxia-telangiectasia (AT) has been performed by studying the expression of the AT phenotype in fused somatic cells or mixtures of cell-free extracts from different patients. Complementation of the defective response to ionizing radiation was observed frequently, considering four different parameters for radiosensitivity in AT. The combined results from studies on cultured fibroblasts or lymphoblastoid cells from 17 unrelated families revealed the presence of at least four and possibly nine complementation groups. These findings suggest that there is an extensive genetic heterogeneity in AT. More extensive studies are needed for an integration of these data and to provide a set of genetically characterized cell strains for future research of the AT genetic defect.


PMID: 3864936

Other references

Silveira, S.-Da; Alfenas, A.; Ferreira, F.; Sutton, J., 2000: Characterization of Rhizoctonia species associated with foliar necrosis and leaf scorch of clonally-propagated Eucalyptus in Brazil. The objective was to identify and characterize the causal agent of foliar necrosis and leaf scorch of Eucalyptus spp. in Brazil. Nineteen putative isolates of Rhizoctonia obtained from Eucalyptus plants during clonal propagation were compared with...

Coulombe, B.; Langelier, M-France., 2005: Functional dissection of the catalytic mechanism of mammalian RNA polymerase II. High resolution X-ray crystal structures of multisubunit RNA polymerases (RNAP) have contributed to our understanding of transcriptional mechanisms. They also provided a powerful guide for the design of experiments aimed at further characterizing...

Sovadinova, I.; Babica, P.; Böke, H.; Kumar, E.; Wilke, A.; Park, J-Suk.; Trosko, J.E.; Upham, B.L., 2016: Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. Plos One 10(5): E0124454-E0124454

Mcclure, G.W.; Hunter, A.S., 1962: Investigations of ammonium chloride as a nitrogen fertilizer for forage crops and corn. At low to moderate rates of nitrogen, crop yield increases from ammonium chloride compared well with those from ammonium sulfate. When high rates of nitrogen as ammonium chloride were broadcast on growing grass, some damage to stand resulted. At h...

Sugimoto, T.; Masuda, T.; Uemura, T.; Tsuneyoshi, M., 1995: Hemangiopericytoma-like intranasal tumor: a case report with an immunohistochemical study. Otolaryngology--Head and Neck Surgery 113(3): 323-327

Vericel, E.; Lagarde, M., 1981: Effect of 15-hydroperoxy-arachidonic acid on platelet functions. Progress in Lipid Research 20: 553-556

Lukacín, S.; Kunay, M.; Poradovský, K., 1975: Antispermatozoal antibodies in the blood and cervical mucus of sterile women. Ceskoslovenska Gynekologie 40(3): 207-208

Ye, F.; Jiang, J.; Chang, H.; Xie, L.; Deng, J.; Ma, Z.; Yuan, W., 2015: Improved single-cell culture achieved using micromolding in capillaries technology coupled with poly (HEMA). Cell studies at the single-cell level are becoming more and more critical for understanding the complex biological processes. Here, we present an optimization study investigating the positioning of single cells using micromolding in capillaries te...

Rimpiläinen, M.; Forsberg, A.; Wolf-Watz, H., 1992: A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH. The plasmid-encoded yop genes of pathogenic yersiniae are regulated by the environmental stimuli calcium and temperature. A novel protein, LcrQ, which exhibits a key function in the negative calcium-controlled pathway, was identified. DNA sequence...

Burkley, Lewis Albert, 2009: Geochronology of the central Venezuelan Andes. Geos (Caracas) 40