+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

D-penicillamine and prussian blue as antidotes against thallium intoxication in rats

, : D-penicillamine and prussian blue as antidotes against thallium intoxication in rats. Toxicology 74(1): 69-76

D-penicillamine (DP) and prussian blue (PB), given alone and in combination, were evaluated in rats as treatments against acute thallotoxicosis. Animals were poisoned by intraperitoneal (i.p.) injection of thallium(I) acetate at different doses (16, 30, 40, 50 and 70 mg/kg). Later (24 h), treatments were administered until day 5, as follows: D-penicillamine (DP), 25 mg/kg, i.p. route, twice daily; prussian blue (PB), 50 mg/kg, oral route, twice daily. LD50 values were estimated for each treatment with the following results: control, 32 mg/kg; DP, 27 mg/kg; PB, 42 mg/kg; PB + DP, 64 mg/kg. Thallium content was analyzed in six body organs and eight brain regions after treatments. PB administration induced significant elimination of thallium from all tissues. DP treatment diminished thallium content in body organs, but increased it in brain regions, indicating a redistributive effect of DP. DP + PB treatment decreased thallium content in all body organs and brain regions. Renal thallium content in the DP + PB group was significantly lower than that of PB alone group, suggesting accelerated urinary excretion of thallium as a result of DP action. Results indicate that DP administered alone may be dangerous because of its redistributive effect, but given in combination with PB may be useful as treatment against thallium poisoning.


PMID: 1514189

Other references

Mckinnon, D., 1982: No regrets over investment in irrigation Sheep farm, profitableness, New Zealand. New Zealand farmer 103(24): 22-23

Geers, B.; Dewitte, H.; D.S.edt, S.C.; Lentacker, I., 2013: Crucial factors and emerging concepts in ultrasound-triggered drug delivery. Time and space controlled drug delivery still remains a huge challenge in medicine. A novel approach that could offer a solution is ultrasound guided drug delivery. “Ultrasonic drug delivery” is often based on the use of small gas bubbles (so-...

Virnstein, RW.; Howard, RK., 1987: Motile epifauna of marine macrophytes in the Indian River Lagoon, Florida. 2. Comparisons between drift algae and three species of seagrasses. Within each of three adjacent monospecific beds of seagrasses (Halodule wrightii Aschersen, Syringodium filiforme Kutzing, and Thalassia testudinum Banks ex Konig) in the Indian River lagoon, Florida, the motile epifauna of seagrass and drift alga...

Mordue, AJ.; Blackwell, A.; Hansson, BS.; Wadhams, LJ.; Pickett, JA., 1992: Behavioural and electrophysiological evaluation of oviposition attractants for Culex quinquefasciatus Say (Diptera: Culicidae). The attraction of gravid C. quinquefasciatus by the oviposition pheromone, erythro-6-acetoxy-5-hexadecanolide, and by polluted water is described. Both materials increase oviposition and when combined the effect is additive. The oviposition behavi...

Costa, M.C.; Silva, G.; Ramos, R.V.; Staempfli, H.R.; Arroyo, L.G.; Kim, P.; Weese, J.S., 2016: Characterization and comparison of the bacterial microbiota in different gastrointestinal tract compartments in horses. The advance of new sequencing technologies has allowed more comprehensive characterization of complex microbial communities, including the ones inhabiting the intestinal tract. The presence of extreme environmental filters, such as low pH, digesti...

Romani, A., 1964: Dangers And Risks In Surgery. Giornale Veneto di Scienze Mediche 19: 263-273

Guerin, H.; Guihard, R.; Strohl, A.; Valeyre, J., 1956: Study of the time constants of frog sciatic nerve fibers. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 150(7): 1300-1301

Epstein Jack Burton, 1958: Faulting, gravity sliding, and brecciation in the Fanny Peak Quadrangle, Black Hills, Wyoming-South Dakota. Geological Society of America Bulletin 69(12, Part 2): 1560

Walsh, J., 1981: AAAS Protests More Cuts for NSF Science Education. Science 211(4487): 1142-1142

Hughes, D.S.; Felbeck, H.; Stein, J.L., 1999: Signal transduction and motility genes from the bacterial endosymbionts of Riftia pachyptila. Cahiers de Biologie Marine. 1998( ); 393-4: 305-308