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DNA damage and repair in mouse liver

, : DNA damage and repair in mouse liver. Archives of Toxicology. Supplement. 10: 162-171

The formation of DNA adducts in mouse liver has been demonstrated for numerous chemicals including members of most major classes of carcinogens. Considerably less is known about the persistence and repair of DNA adducts in mouse liver. Likewise, major gaps in present knowledge exist regarding the molecular dosimetry of DNA adducts and their potential for miscoding during continuous exposure to high versus low doses of carcinogens. A prime example of this is 2-acetylaminofluorene (2-AAF), the carcinogen used in the ED01 megamouse study. There are no molecular dosimetry studies on the DNA adducts of 2-AAF, even though such a unique data base exists for the dose-response relationship of mouse liver tumors. Reviewing the pertinent literature, identifying deficiencies, and conducting the required research will hopefully permit a better determination of the relevance of mouse liver tumors to man.


PMID: 3107521

Other references

Patel, H., 1981: Experience with the cerebral function monitor during deliberate hypotension. Forty-five healthy patients (30 aged 15-46 yr and 15 aged 58-82 yr) undergoing various types of plastic surgery were studied during deliberate hypotension produced by a combination of ganglion- and beta-blockade, halothane, head-up tilt and positi...

Datta, A.; Dave, D., 2016: Effects of Physician-directed Pharmaceutical Promotion on Prescription Behaviors: Longitudinal Evidence. NlmCategory="UNASSIGNED">Spending on prescription drugs (Rx) represents one of the fastest growing components of US healthcare spending and has coincided with an expansion of pharmaceutical promotional spending. Most (83%) of Rx promo...

Przyklenk, K., 1998: Brief antecedent preconditioning ischemia accelerates coronary thrombolysis in the canine model. Journal of the American College of Cardiology 31(2 SUPPL A): 66A, Feb

Randall, B.A., 1886: A Modified Loring Ophthalmoscope, with a Disk of Cylindrical-Lenses. Transactions of the American Ophthalmological Society 4: 343-345

Mccracken D.A.; Cain J.R., 1981: Amylose in floridean starch. Seven members of the Porphyridiales [Chroothece, Rhodella, Glaucosphaera, Porphyridium, Flintiella, Rhodosorus and Asterocytis] and a member of the Bangiales (Erythrocladia) demonstrated conclusively the presence of amylose in red algal starch.

Gomella, L.G.; Mann, M.J.; Cleary, R.C.; Hubosky, S.G.; Bagley, D.H.; Thumar, A.B.; McCue, P.A.; Lallas, C.D.; Trabulsi, E.J., 2017: Fluorescence in situ hybridization (FISH) in the diagnosis of bladder and upper tract urothelial carcinoma: the largest single-institution experience to date. We evaluated the UroVysion (Abbott Molecular, IL, USA) fluorescence in situ hybridization (FISH) assay for the diagnosis of urothelial cancer in patients diagnosed with or suspected to have bladder, upper tract urothelial carcinoma (UTUC), and com...

Shemer, A.; Whitaker-Azmitia, P.M.; Azmitia, E.C., 1988: Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat. Parachlorophenylalanine (pCPA) or 5-methoxytryptamine (5MT) was administered to pregnant Sprague Dawley rats from day 8 (D8) of gestation till D17 and from D12 until birth respectively. Birth weights of both drug groups of neonates were approximat...

Vos, T.; Flaxman, A.D.; Naghavi, M.; Lozano, R.; Michaud, C.; Ezzati, M.; Shibuya, K.; Salomon, J.A.; Abdalla, S.; Aboyans, V.; Abraham, J.; Ackerman, I.; Aggarwal, R.; Ahn, S.Y.; Ali, M.K.; Alvarado, M.; Anderson, H.Ross.; Anderson, L.M.; Andrews, K.G.; Atkinson, C.; Baddour, L.M.; Bahalim, A.N.; Barker-Collo, S.; Barrero, L.H.; Bartels, D.H.; Basáñez, M-Gloria.; Baxter, A.; Bell, M.L.; Benjamin, E.J.; Bennett, D.; Bernabé, E.; Bhalla, K.; Bhandari, B.; Bikbov, B.; Bin Abdulhak, A.; Birbeck,, 2013: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to qu...

Reed, J., 1996: Psychopathy--a clinical and legal dilemma. British Journal of Psychiatry 168(1): 4-9

Connolly, J., A.; Miller, K., S.; Mcaninch, J., W., 1995: Penile intracavernous hematoma: Diagnosis and surgical considerations. Soft tissue lesions of the penile corporeal bodies are rare and usually represent benign or malignant tumors, or Peyronie's disease. We report a unique case of a deep seated penile mass that at exploration proved to be an encapsulated hematom...