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Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice


, : Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130(6): 3378-3386

CRF is released in response to various stressors and regulates ACTH secretion and glucocorticoid production. CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome. To test whether CRF overproduction leads to Cushing's syndrome and to develop an animal model of chronic pituitary-adrenal activation, the CRF gene was expressed under control of the metallothionein promoter in transgenic mice. CRF transgenic animals exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. These animals display physical changes similar to those of patients with Cushing's syndrome, such as excess fat accumulation, muscle atrophy, thin skin, and alopecia. These findings indicate that chronic production of excess CRF results in sustained stimulation of pituitary corticotrope cells, resulting in elevated ACTH and consequent glucocorticoid overproduction, a condition that leads to the development of Cushing's syndrome. Analysis of CRF mRNA distribution revealed that transgene expression is primarily restricted to cells that express the endogenous CRF gene and does not follow the pattern predicted of a metallothionein-regulated gene. These results suggest that DNA elements located outside of the CRF promoter but present within the CRF intron, coding, or 3'-flanking regions may contribute to the cell type specificity of CRF gene expression.

US$19.90

PMID: 1597149

DOI: 10.1210/endo.130.6.1597149


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X.J.e; Wang Guoquan; L.X.aozhao, 1999: Preliminary research on the potential effect of underground engineering on ground water environment. In this paper, preliminary research on the potential effects of underground engineering on groundwater environment is discussed. The effects are mainly as follows: blocking of ancient water channels, causing a fluctuation in groundwater level, and...

Gollucke, A.P.B.; Taniwaki, M.H.; Tavares, D.Q., 2004: Survey on ochratoxin A in Brazilian green coffee destined for exports. The presence of ochratoxin A (OTA) in foods has led some countries to establish regulatory limits. Although coffee is not a major source of OTA in human consumption, the European Community (EC) may establish limits in the near future, with possibl...

Thelot, J-P., 1980: Recherche sur la fauna endogee: description de deux nouvelles especes de Leptotyphlinae du Var (France) (coleopteres Staphylinidae). Leptotyphlus varagensis sp. nov. and L. brescius sp. nov. from Var (France) are described. Taxonomic notes on 2 subgenera (Leptotyphlus s.s. and Odontotyphlus Coiff.) are presented.

Deftereos, S.N.; Panagopoulos, G.; Gryllia, M.; Georgonikou, D.; Polyzoi, M.; Kechagias, E.; Aessopos, A.; Karageorgiou, C.E., 2007: Neurophysiological monitoring of brainstem function in a patient with Wallenberg syndrome, using Vestibular Evoked Myogenic Potentials. We evaluated the use of Vestibular Evoked Myogenic Potentials (VEMPs) in the assessment of neural function, following medullary lesions. A 54-year-old male presented with symptoms and signs typical of right lateral medullary (Wallenberg) syndrome....

Smith, M., 1974: Minors and contraception. British Medical Journal 3(5922): 46-46

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Gilbert H.F.; Cappel R.E.; Kruzel M.L.; Morjana N.A., 1992: Detection of a partially proteolyzed disulfide linked dimer of 3 hydroxy 3 methylglutaryl coa reductase in rat liver. Biophysical Journal 61(2 PART 2): A36

Huba, J.; Peskovicova, D.; Chrenek, J.; Kmet, J., 1996: Comparison of fertility traits in Slovakian Pieds and Holsteins and their crosses. A least-squares analysis of 10 896 reproductive performance records of Slovakian Pied (SP), Holstein and Holstein x SP cows was carried out. The crossbreds comprised groups with 50-96.8% Holstein inheritance. The traits analysed were interval from...

FitzPatrick, I.; Indefrey, P., 2010: Lexical competition in nonnative speech comprehension. Electrophysiological studies consistently find N400 effects of semantic incongruity in nonnative (L2) language comprehension. These N400 effects are often delayed compared with native (L1) comprehension, suggesting that semantic integration in one...

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