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Development of location-specific hair cell stereocilia in denervated embryonic ears


, : Development of location-specific hair cell stereocilia in denervated embryonic ears. Journal of Comparative Neurology 288(4): 529-537

The developmental mechanisms that allow physiological coding of acoustic pitch have remained unexplained. Cochlear hair cells that have different structures respond to different sound frequencies and synapse with neurons that project to different locations in the brain. How do these hair cells develop appropriate structures, and how are the connections between specific hair cells and the neurons that code for their pitch sensitivities matched? We have investigated one aspect of this by denervating embryonic chicken ears, before the time of hair cell production, and then transplanting them to the aneural chorioallantoic membrane of host embryos where they have continued to develop. We report that vestibular and auditory hair cell phenotypes differentiate appropriately and that correct gradients of hair cell structural phenotypes, as expressed in stereocilia bundles, develop in the cochleae of these denervated ears. Therefore, the normal development of gradients in hair cell stereocilia properties must be controlled by location-specific cues originating in the ear itself. Neuronally directed modification of target cell phenotypes is not required for the quite specific phenotype development represented by the stereocilia bundles of individual hair cells and the connectional matching in the numerous distinct peripheral information lines of the auditory system.

US$19.90

PMID: 2808748

DOI: 10.1002/cne.902880402


Other references

Kisteneva, G.S., 1964: Energy expenditure of children at different stages of infectious hepatitis. Energy exchange was studied by indirect calorimetry in 30 children, 8 to 14 years old, with infectious hepatitis. In the first period of the disorder, up to the 10th day, it was somewhat lower for the same types of activity than in the second and...

Frank, R.J.; Damasio, H.; Grabowski, T.J., 1997: Brainvox: an interactive, multimodal visualization and analysis system for neuroanatomical imaging. A study of cognition emerging from a neurobiological perspective, as opposed to one emerging from a purely computational or psychological perspective, begins with observations of the human brain in normal and pathological states and is furthered b...

Shrotri S.C.; Gupta J.S.; Srivastava R.N., 1987: Histopathological studies on dahlia seeds. Six fungi [Aspergillus flavus, Alternaria alternata, Curvularia pallescens, Fusarium moniliforme, F. monifliforme, var. subglutinans and Phoma putaminum] were found to be associated with sterilized pericarp, seedcoat and embryo of Dahlia variabili...

Klootwyk Chris T. (Klootwijk Chris T), 1980: The India-Asia collision, underthrusting of the Tibetan Plateau and post-collisional deformation of south central Asia; implications from new palaeomagnetic data. Pages 101-102 1980

Pietrobon, R.; Zaveri, A.; Cofiel, L.; Barros, J.; Shah, J., 2010: Computational ontologies in orthopaedic surgery. Information Technology (IT) plays an important role in storing and collating the vast amounts of healthcare data. However, analyzing and integrating this data to extract useful information is difficult due to the heterogeneous, siloed, disparate,...

Campbell E.J.; Macrae T.H., 1989: Microtubule cross linking proteins from artemia. Warner, A H , T H Macrae And J C Bagshaw (Ed ) Nato Asi (Advanced Science Institutes) Series Series A: Life Sciences, Vol 174 Cell And Molecular Biology Of Artemia Development; Workshop, Montreal, Quebec, Canada, August 11-13, 1988 X+453p Plenum Publishing Corporation: New York, New York, Usa; London, England, Uk Illus 409-410

Hall-Pogar, T.; Zhang, H.; Tian, B.; Lutz, C.S., 2005: Alternative polyadenylation of cyclooxygenase-2. A biologically important human gene, cyclo-oxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased...

Lestage, J.A., 1922: La presence en Belgique de Sympherobius striatellus Klp. Bulletin de la Societe Entomologique de Belgique Bruxelles, 4: 103

Mirolli M., 1983: Inward and outward currents in isolated dendrites of crustacea portunus sanguinolentus coxal receptors. Segments from the nonspiking peripheral dendrites of a crustacean coxal receptor (T fiber) were studied using the voltage clamp technique. The periperal endings of the T fiber are sensitive to stretch applied to a specialized receptor muscle by ro...

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