geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Developmental expression and androgenic regulation of the mRNA for major secretory proteins of the rat epididymis


, : Developmental expression and androgenic regulation of the mRNA for major secretory proteins of the rat epididymis. Molecular and Cellular Endocrinology 53(1-2): 59-66

The concentration of the mRNAs for two pairs of androgen-dependent secretory proteins of the rat epididymis has been measured by filter hybridization with cDNA during the course of post-natal development and following castration and androgen replacement of adult animals. The rate of synthesis of the secretory proteins, measured in an in vitro incubation system, was also ascertained during post-castration involution of the epididymis and during subsequent androgen replacement. The mRNAs for the proteins were first detected at 20 days of age and their levels increased rapidly to reach near adult levels between 30 and 40 days. In the caput epididymidis the levels of the mRNAs declined rapidly during the first week after castration and became undetectable by 16 weeks. Administration of testosterone propionate to animals castrated for 16 weeks reinduced the levels of mRNAs to maximum values by 1 week, but for one pair of proteins the reinduced maximum was only 30% of precastration values. This result, in conjunction with other information, is suggestive that this pair of proteins is under multihormonal control. In the cauda epididymidis, the kinetics of change in mRNA level during androgen withdrawal and replacement were slower than in the caput. In all instances, changes in the rate of synthesis of the secretory proteins followed by observed changes in their level of mRNA, suggesting an absence of androgenic control of translation in the epididymidis.

US$29.90

PMID: 3666293


Other references

Molostovskaya, Ijia I., 1997: Stratigraphic correlation of the Upper Permian deposits from the south of the Cis-Ural marginal Trough and the adjacent areas of the Russian Plate. Studied in detail were about 100 sections of the Upper Permian marine and continental deposits from the South Cis-Urals: from the south-eastern edge of the Russian Place and the Cis-Ural Trough. Characteristic complexes of marine and non-marine os...

Reichert, P., 1972: A backward look at the Food and Drug Administration from the twenty-first century. Journal of Clinical Pharmacology and New Drugs 12(8): 301-302

Clark A.G., 1990: Genetic components of variation in energy storage in drosophila melanogaster. One approach to examining the underlying genetic structure of the variation in a continuous phenotype is to measure a set of possibly mechanistically related traits and determine the quantitative genetic aspects of their transmission. In this stud...

Schiffer D.; Giordana M.T.; Mauro A.; Migheli A.; Germano I.; Giaccone G., 1986: Immunohistochemical demonstration of vimentin in human cerebral tumors. The distribution of vimentin (VIM) has been histochemically investigated in 53 cerebral tumor and compared in gliomas to that of glial fibrillary acidic protein (GFAP). In gliomas VIM is less positive than GFAP, but shows the same distribution. It...

Szira,F.; Balint,A.F.; Borner,A.; Galiba,G., 2008: Evaluation of drought-related traits and screening methods at different developmental stages in spring barley. Despite intensive research and breeding efforts, the physiological and quantitative genetic bases of drought tolerance are still poorly understood. The comparison of results obtained from different sources is also complex, because different testin...

Hayashi K., 1989: Comparative study on the responses of human neutrophils and eosinophils to platelet activating factor. Platelet-activating factor (PAF) is known as one of the chemical mediators to induce inflammation and allergy, and is generated by various cell types. The direct effects of PAFs on neutrophils and eosinophils were assessed using several biological...

Dobrev, K.; Donev, L., 1970: Preharvest desiccation of potato bushes with chemical formulations. Application of Na-PCP to potatoes infected with Phytophthora infestons before harvest accelerated leaf desiccation and gave effective control of P. infestons, thus preventing its carry-over in stored tubers.

Maithy P.K., 1980: Neoscytonema, a new name for Palaeoscytonema Maithy & Shukla. Geophytology 10(1-2): 280

Braddon, SA.; McIlvaine, CM.; Balthrop, JE., 1985: Distribution of GSH and GSH cycle enzymes in black sea bass (Centropristis striata). 1.1. Tissue extracts were prepared from black sea bass kidney, liver, brain, red blood cells and muscle; each of the extracts was analyzed for the following glutathione (GSH)-dependent enzyme activities: Se-dependent and Se-independent GSH-peroxid...

Hofmann, M., 1985: ER-post system in the reconstruction of pulp devitalized teeth (II). Die Quintessenz 36(2): 263-270