+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dual actions of prostacyclin (PGI2) on the rat pregnant uterus

, : Dual actions of prostacyclin (PGI2) on the rat pregnant uterus. Prostaglandins 17(5): 667-672

Using strips of rat pregnant uterus, treated with indomethacin to suppress spontaneous contractility, the oxytocic activity of prostacyclin was compared with other prostaglandins. A prostacyclin concentration of 32 ng/ml elicited uterine contractions in all experiments. In this respect prostacyclin was 80 times more active than 6-oxo-PGF1 alpha but less active than PGE2 or PGF2 alpha. Apart from a direct stimulant effect, prostacyclin also exhibited an indirect potentiating action. In threshold concentrations prostacyclin caused a 3-fold potentiation of threshold doses of oxytocin. A lesser 1.5-fold potentiation of PGE2 alpha was also observed. The implications of these findings in relation to prostacyclin playing a role in parturition are discussed.


PMID: 386426

Other references

Nunberg, M., 1946: Acantholyda nemoralis C. G. Thoms, in Poland.. Acantholyda pinivora, Ensl. (nemoralis, Thoms., stellata, Christ) all stages of which are described, occurs in pine forests throughout Poland and is abundant in the regions of Cracow and Upper Silesia, where some 77 sq. miles of forest is infested...

Cook, T., 1982: Grass in the nursery? Turf strips between nursery crop plantings. Ornamentals northwest newsletter Cooperative Extension Service Oregon State Univeristyt 6(3): 11-14

Ngai, J.C.F.; Mak, P-In.; Siu, S.W.I., 2016: ProtPOS: a python package for the prediction of protein preferred orientation on a surface. Atomistic molecular dynamics simulation is a promising technique to investigate the energetics and dynamics in the protein-surface adsorption process which is of high relevance to modern biotechnological applications. To increase the chance of suc...

Burger, K.; Koehler, T.; Chabior, M.; Allner, S.; Marschner, M.; Fehringer, A.; Willner, M.; Pfeiffer, F.; Noël, P., 2015: Regularized iterative integration combined with non-linear diffusion filtering for phase-contrast x-ray computed tomography. Phase-contrast x-ray computed tomography has a high potential to become clinically implemented because of its complementarity to conventional absorption-contrast.In this study, we investigate noise-reducing but resolution-preserving analytical rec...

Rassow J.; Strueter H D.; Lacin E., 1970: Undesirable secondary radiation in the irradiation space of a siemens 42 mev betatron. U S Government Research & Development Reports 70(4): 49

Larson, S.D.; Kastner, R.J., 1996: Compositions and methods for use in aquaculture. Official Gazette of the United States Patent & Trademark Office Patents 1191(4): 2631, Oct 22

Buser, P., 1962: Functional Role And Setting Into Action Of Certain Corticofungal Pathways. Actualites Neurophysiologiques 4: 67-89

Baldelli P.; Angeli D.D.; Dellocchio T.; Dolara A.; Manetti A.; Salvatore L., 1972: Silent mitral stenoses. Giornale Italiano di Cardiologia 2(3): 365-369

Lee, K.H.; Wucherpfennig, K.W.; Wiley, D.C., 2001: Crystal structure of HLA-DQ8 Human MHC class II molecules associated with susceptibility to type I diabetes. Biophysical Journal 80(1 Part 2): 60a, January

Wu, L.; Liang, W.; Chen, W.; Li, S.; Cui, Y.; Qi, Q.; Zhang, L., 2017: Screening and Analysis of the Marker Components in Ganoderma lucidum by HPLC and HPLC-MS n with the Aid of Chemometrics. <i>Ganoderma</i> triterpenes (GTs) are the major secondary metabolites of <i>Ganoderma lucidum</i>, which is a popularly used traditional Chinese medicine for complementary cancer therapy. The present study was to establish...