+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Early-morning dystonia. A late side effect of long-term levodopa therapy in Parkinson's disease

, : Early-morning dystonia. A late side effect of long-term levodopa therapy in Parkinson's disease. Archives of Neurology 36(5): 308-310

Four women with Parkinson's disease undergoing prolonged levodopa therapy had daily episodes of dystonic posturing, affecting one lower extremity, several years after initiation of treatment. The dystonia occurred only in the early morning, on awakening and before the first dose of levodopa, when the patients were in the akinetic-rigid state with no dyskinesias. It further interfered with gait, slowly subsided within one to two hours, and did not recur until next morning. This abnormal involuntary posture was unaffected by manipulations of daily levodopa dosage and schedule, completely disappeared after withdrawal of drug therapy, and recurred following its readministration. Additional adverse reactions including dyskinesias, "on-off" phenomena, and declining efficacy of levodopa were present in all patients. Early-morning dystonia may represent another late side effect secondary to long-term levodopa administration in parkinsonism.


PMID: 444100

Other references

Ding, Y., 2001: Other schools go first with narrower approach. Science 293(5535): 1616-1616

Kempler, L.; Sharpe, L.; Miller, C.B.; Bartlett, D.J., 2015: Do psychosocial sleep interventions improve infant sleep or maternal mood in the postnatal period? A systematic review and meta-analysis of randomised controlled trials. Sleep complaints are common amongst mothers of infants and insufficient, inefficient or fragmented sleep is associated with postnatal depression. The aim of this review is to determine whether psychosocial sleep-focused interventions offered in th...

Kemeny, N., 2006: Management of liver metastases from colorectal cancer. The liver is a frequent site of metastatic colorectal disease. Over the past 20 years, improvements in systemic chemotherapy and surgical techniques have improved the survival of patients with hepatic metastases. For 4 decades, fluorouracil and le...

Miyazaki, Y., 1970: Surgery of bilateral cerebral aneurysm, with special reference to bilateral craniotomy and simultaneous direct surgery. Shujutsu. Operation 24(1): 17-28

Lambert, B.; Lessard, M., 1987: Massive ovarian edema in a twin pregnancy. A case of idiopathic ovarian edema in a 26-year-old woman with a twin pregnancy is reported. The clinical evolution of the condition was benign in spite of acute episodes of left iliac pain. In diagnosis, theca-lutein cysts had to be differentiate...

Zhou, Q.; Verdoom, T.A.; Beechem, J.M.; Lovinger, D.M., 1997: Alcohols increase activation and stabilize the open state of 5-HT-3 receptors on NCB20 neuroblastoma cells A kinetic and modeling study. Alcoholism Clinical & Experimental Research 21(3): 6A

Zuk, L.; Tlumek, H.; Katz-Leurer, M.; Peretz, C.; Carmeli, E., 2015: A new tool for identifying children with motor problems: reliability and validity study. This study examined reliability and validity of the Zuk Assessment for diagnosis of motor problems and determined standardized scores in an Israeli population aged 5 to 6 years. For standardization, 156 children recruited from 13 Kindergartens of...

Doult, B., 1995: NHS patient payouts hit record £125m. NlmCategory="UNASSIGNED">Clinical compensation payments to NHS patients have risen by a quarter within a year.

Nemeth I.; Boda D., 1981: Determination of urate concentration by uv light absorbance change produced on oxidation with alkaline ferri cyanide. Clinica Chimica Acta 113(2): 223-227

Nam T.J.; Pyeun J.H., 1983: Alkaline protease activity of the tissue extracts from some different kinds of fish. Extracts of muscle, alimentary canal, liver, spleen, hepatopancreas and pancreas and kidney from the omnivorous filefish (Navodon modestus), carnivorous cat shark (Scylliorhinus torazame) and bloodsucking hagfish (Eptatretus burgeri) were sampled....