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Effect of alloxans on pancreatic B-cells with special regard to the alloxan-metal-complex theory. I. Effects of alloxan, alloxan-zinc chelates, dilauric acid and colchicine on blood sugar and rate of mitosis of B-cell Langerhans islets


, : Effect of alloxans on pancreatic B-cells with special regard to the alloxan-metal-complex theory. I. Effects of alloxan, alloxan-zinc chelates, dilauric acid and colchicine on blood sugar and rate of mitosis of B-cell Langerhans islets. Acta Histochemica 88(1): 29-46

Alloxan, alloxan-zinc-chelate, sodium salt of dialuric acid, and colchicine significantly raised the blood sugar level under the previously mentioned experimental conditions 28 h after the application. The typical three-phase blood sugar curve development after alloxan (initial hyperglycemia, hypoglycemia, permanent hyperglycemia) was only approximately reached by dialuric acid which initiated, however, instead of the initial hyperglycemia a more pronounced hypoglycemic phase within the first 6 h. Alloxan-zinc-chelate protractedly and significantly made the blood sugar's increase up to the 7th d post injectionem, without being able to maintain a permanent hyperglycemia with half-normal dosage in comparison with alloxan. Non-diabetogenic alloxan doses (19 mg/kg i. v.) and the appropriate alloxan-zinc-chelate dosage (35 mg/kg) led to a significant increase of the blood sugar only in the chelate group with the long-term test up to 10 d, suggesting an increased and prolonged effect of the metal-chelates by stabilization of alloxan. The tested substances differently acted on the mitotic frequency of B-cells. The mitosis did not increase in the alloxan-zinc- and dialuric acid treated animals and was similar to normal animals far below the fractions of 1/10(6). A 4- and 5-fold increase of the mitotic frequency in the colchicine or alloxan treated animals as well as an accumulation of delayed metaphases suggest an impeded transition to the anaphase and include alloxan among the mitotic poisons.

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PMID: 2113338


Other references

Tranchina, D.; Sneyd, J.; Cadenas, I.D., 1991: Light adaptation in turtle cones. Testing and analysis of a model for phototransduction. Light adaptation in cones was characterized by measuring the changes in temporal frequency responses to sinusoidal modulation of light around various mean levels spanning a range of four log units. We have shown previously that some aspects of con...

McConnel, F.M.; Hester, T.R.; Nahai, F.; Jurkiewicz, M.J.; Brown, R.G., 1981: Free jejunal grafts for reconstruction of pharynx and cervical esophagus. Reconstruction of the pharynx and cervical esophagus is a surgical challenge associated with high complications, multiple-staged procedures, and prolonged hospitalizations. In a series of cases, single-stage transfer-free jejunal graft reconstruct...

Fedotova, NA., 1984: On the cyclic changes of zooplankton biomass off the south-western Sakhalin. Izvestiya Tikhookeanskogo Nauchno-Issledovatel'skogo Instituta Rybnogo Khozyaistva I Okeanografii, 83-85 No. 109

von Blotzheim, S.G.; Borruat, F.X., 1996: Neuro-ophthalmological complications of Horton's disease. Revue Medicale de la Suisse Romande 116(1): 21-25

MacNaughton, N.S.; Jones, M.L., 2014: Health concerns of Micronesian peoples. Several states in the United States have been experiencing an influx of migrants from an area of the world that most people have only heard of when learning about the atomic bomb and World War II. This area is the former U.S. Trust Territory of Pa...

Yih W.K., 1989: The effects of plant litter and inorganic fertilizer on crop weed interactions in a temperate rich soil site. Litter (mulch) may have potential for sustaining low-technology agriculture in at least two capacities: as a nutrient source and as weed control. This experiment discriminates between these two possible effects at a temperate site in Michigan, U.S...

D.B.ndt, M.; Palazzo, E.; Belmatoug, N.; M'Bappe, P.; Hayem, G.; Kahn, M.F.; Meyer, O., 2000: Outcome of pregnancies in lupus: experience at one center. We determined the outcome of all pregnancies in SLE patients in our lupus cohort between 1991 and 1997. The women were advised that pregnancy was acceptable if the disease had been inactive for 6 months (SLEDAI < or = (4 at 2 serial examination...

Mariana, A.; Santana, R., A.S.; Tan, S.N.; Ho, T.M., 2007: Scanning electron micrographs of Blomia tropicalis (Acari : Astigmata : Echimyopodidae), a common house dust mite in Malaysia. Many finer taxonomic characters of Blomia tropicalis are not distinctly visible under conventional light microscopy. Scanning electron micrographs of this mite are therefore presented in this paper for better appreciation of the inconspicuous feat...

Maxson John Haviland, 1950: Physiographic features of the Panamint Range, California. Geological Society of America Bulletin 61(2): 99-114

Dunne, C.P.; Gerlt, J.A.; Rabinowitz, K.W.; Wood, W.A., 1973: The mechanism of action of 5'-adenylic acid-activated threonine dehydrase. IV. Characterization of kinetic effect of adenosine monophosphate. Journal of Biological Chemistry 248(23): 8189-8199