geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of co-administration of granulocyte colony-stimulating factor on interferon therapy


, : Effect of co-administration of granulocyte colony-stimulating factor on interferon therapy. Japanese Journal of Cancer Research 82(3): 346-350

The effect of co-administration of granulocyte colony-stimulating factor (G-CSF), as an antineutropenia agent, on interferon therapy was examined in a mouse model, in anticipation of an enhancement of interferon efficacy, because neutrophils induced by G-CSF are thought to act as antitumor effectors. G-CSF was intraperitoneally co-administered with human interferon alpha A/D (IFN) on Day 6 to Day 10 after intradermal inoculation of Meth A fibrosarcoma. Although the co-administration of G-CSF could protect against neutropenia and leukopenia induced by IFN, it did not enhance the regression of tumor, and rather reduced the prolongation of survival time and the long-term survival incidence of IFN therapy. The subsequent in vitro study showed that the antiproliferative activity of peripheral blood leukocytes from Meth A-bearing mice given both IFN and G-CSF was much weaker than that of mice given IFN alone. Whether the observed nullifying effect of G-CSF on IFN therapy is also the case with tumors other than Meth A is open to further study.

US$29.90

PMID: 1708757


Other references

Reading, C.L.; Kraemer, P.M.; Miner, K.M.; Nicolson, G.L., 1983: In vivo and in vitro properties of malignant variants of RAW117 metastatic murine lymphoma/lymphosarcoma. Using the RAW117 lymphoma/lymphosarcoma system syngeneic to Balb/c strain mice, variant sublines have been selected for enhanced blood-borne liver colonization in vivo or for lack of binding to immobilized lectins in vitro. The kinetic organ distr...

Bijlsma, M.W.; Brouwer, M.C.; Bossuyt, P.M.; Heymans, M.W.; van der Ende, A.; Tanck, M.W.T.; van de Beek, D., 2016: Risk scores for outcome in bacterial meningitis: Systematic review and external validation study. To perform an external validation study of risk scores, identified through a systematic review, predicting outcome in community-acquired bacterial meningitis. MEDLINE and EMBASE were searched for articles published between January 1960 and August...

Yoel, Jose, 1994: Surgery of the Pterygomaxillary fossa. Prensa Medica Argentina 81(6): 545-553

Denston, C.S., 1948: Chronic periapical lesions; a detailed study of their pathology incidence and clinical significance, with special reference to those occurring on deciduous teeth. Dental Journal of Australia 20(1): 1-19

Baskaya, M.K.; Prasad, M.R.nuka; Donaldson, D.; Hu, Y.; Rao, A.M.ralikrishna; Dempsey, R.J., 1996: Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. Cerebral ischemia is well known to cause an increase in the level of free fatty acids (FFAs) in rodent species. Such FFA accumulations may signal regional lipid membrane damage and are postulated to participate in the pathogenesis of progressive i...

Bruhn, J.G.; Rogers, P.J.; Torres, M.C., 1980: A model for a health career information center. A model health career information center was developed and evaluated at a university health science center. One part of the information center is a statewide, toll-free health careers hotline which provides information about health careers to high...

Watanabe, M.; Kurai, J.; Sano, H.; Shimizu, E., 2015: Effect of exposure to an Asian dust storm on fractional exhaled nitric oxide in adult asthma patients in Western Japan. Epidemiological investigations indicate that an Asian dust storm (ADS) can aggravate respiratory disorders. However, the effects of ADS on airway inflammation remain unclear. The aim of this study was to investigate the association of exposure to...

Astilleros Garcia Monge J.M.; Lopez Andres S.; Fernandez Diaz L.; Pina C.M., 1995: Malachite crystallization in porous media; nucleation characteristics and morphologic evolution. Boletin Sociedad Espanola de Mineralogia 18(2): 39-40

Wilkaniec,B.; Piekarska-Boniecka,H., 2008: Aphid infestation of decorative perennials. The many years' study on species composition and harmfulness of aphids infesting perennials in the decorative plant collection Agricultural University in Poznan permitted to ascertain occurrence of 23 aphid species on 66 species of decorative...

Keller, M.S.; Weltin, G.G.; Rattner, Z.; Taylor, K.J.; Rosenfield, N.S., 1988: Normal instability of the hip in the neonate: US standards. In recent years, the use of real-time ultrasonography (US) has enabled dynamic evaluation of the infant hip through a range of motion and stress. Preliminary experience has suggested that a certain amount of instability in the hips of newborns is...