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Effect of ethanol on cyclic nucleotides in vivo: consequences of controlling motor and respiratory changes

, : Effect of ethanol on cyclic nucleotides in vivo: consequences of controlling motor and respiratory changes. Drug and Alcohol Dependence 4(3-4): 321-326

Many psychotropic drugs alter cerebellar cyclic guanosine-3',5'-monophosphate (cGMP) content. Whereas apomorphine increased levels, central depressants such as ethanol, chlordiazepoxide or barbiturates, reduce the content of cerebellar cGMP without altering levels of cyclic adenosine-3',5'-monophosphate (cAMP). Additional data indicate that tolerance develops to this reduction of cerebellar cGMP by ethanol. In paralyzed animals, the increase in cerebellar cGMP content induced by apomorphine and the decrease caused by ethanol were dramatically attenuated. Since relatively high doses of ethanol were needed to decrease blood CO2 tension in spontaneously moving rats, changes in respiratory function appear to be of only minor importance in the ethanol-induced decrease in cerebellar cGMP. It is concluded that ethanol-induced changes in content of cerebellar cGMP in vivo may be secondary to alterations in motor and, to a lesser extent, in respiratory function.


PMID: 230951

Other references

Dimitriu, C.G.; Zeană, C., 1971: Bronchial asthma associated with tracheobronchial expiratory collapse (considerations on a case). Medicina Interna 23(6): 741-744

Phillips, P.L.; Barnes, P.W., 2003: Spatial Asymmetry in Tree-shrub Clusters in a Subtropical Savanna. Plateau live oak (Quercus virginiana var. fusiformis) is thought to act as a nurse plant to other woody species in the upland savannas of the Edwards Plateau of central Texas; however, little is known of the nature, extent and duration of this fac...

Lim, A.S.T.; Lim, T.H.; Kee, S.K.; Chieng, R.; Tay, S.K., 2003: Sperm segregation patterns by fluorescence in situ hybridization studies of a 46,XY,t heterozygote giving rise to a rare triploid product of conception with a 69,XXY,t der t pat karyotype. A blighted ovum diagnosed initially by ultrasound was determined to be a partial hydatidiform mole with a 69,XXY,t(2;6)(p12;q24) der(6)t(2;6)(p12;q24)pat karyotype by cytogenetic analysis. The triploid state arose through dispermy in which both sp...

Beel, E.; Schelstraete, A., 1979: Research on the culture and manuring of Calathea makoyana. II. In a substrate consisting of 3:1 coniferous litter:peat the optimum dose of Gold N, a 30% N slow-release fertilizer, was 300 mg/litre for 2 consecutive crops of C. makoyana. In 2:1 coniferous litter: peat the optimum dose of Triabon (20:10:15:5 NP...

Calon, Fédéric.; Dridi, M.; Hornykiewicz, O.; Bédard, P.J.; Rajput, A.H.; D.P.olo, Térèse., 2004: Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias. Brain adenosine A2A receptors have recently attracted considerable attention because of their interaction with the dopaminergic system and as potential targets for Parkinson's disease pharmacotherapy. Post mortem adenosine A2A receptor mRNA a...

Cox L.J.; Craig J.R.; Kazda R.F., 1979: The Arminius; a volcanogenic massive sulfide deposit in the Mineral District, Louisa County, Virginia. Abstracts with Programs - Geological Society of America 11(4): 175

Kirby, S.E.; Yardley, L., 2009: Cognitions associated with anxiety in Ménière's disease. The purpose of this longitudinal study was to identify cognitions associated with anxiety and maintenance of anxiety in people with Ménière's disease. At baseline, participants completed the Hospital Anxiety and Depression Scale (HADS), the...

Torres, V.; Lopez, V.; Noda, A., 1993: Example for the application of multivariate techniques in different stages of the evaluation and screening of pasture species: II. Multivariate analysis of variance. An example for the application of the multivariate analysis of variance (MANOVA) is presented in the evaluation and screening process where five species submitted to cutting are evaluated. The experiment lasted three years and it was possible to c...

Luebs, Re, 1970: Use nitrogen cautiously on dryland barley. Crops and soils: 22 (5) 22-23

Talwar P.K., 1970: Cantor a new generic name for bola cuja pisces sciaenidae. Advance Abstracts of Contributions on Fisheries & Aquatic Sciences in India 4(3): 279