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Effect of opiate agonists administered intrathecally on the behavioral and hemodynamic manifestations of pain


, : Effect of opiate agonists administered intrathecally on the behavioral and hemodynamic manifestations of pain. Farmakologiia i Toksikologiia 51(1): 23-25

An agonist of mu-opiate receptors, D-Ala2-Gly-ol5-enkephalin (DAGO, 0.5 mcg), administered intrathecally, was found to inhibit behavioral and hemodynamic reactions induced by thermal and electrical stimulation of conscious male rats. D-Ala2-D-Leu-enkephalin (DADL, 0.5 mcg), acting on delta-receptors, was shown to potentiate nociceptive shifts of arterial blood pressure. Phencyclidine and bremazocine failed to exert any significant effect on the opioidergic mechanisms of the spinal cord.

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PMID: 2834219


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