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Effect of pH value and magnesium on the antibacterial activity of quinolone preparations

, : Effect of pH value and magnesium on the antibacterial activity of quinolone preparations. Infection 14 Suppl 1: S31-S35

The activity of ten different 4-quinolone antibacterial agents against Escherichia coli KL16 was investigated at four pH values between 5.6 and 8.3, which is the pH range of urine. It was found that pH affected the minimum inhibitory concentrations of all the drugs, but the nature of the substituent at the C7 position of each 4-quinolone governed how its activity was altered by the hydrogen ion concentration. When a 4-quinolone possessed a piperazine group at its C7 position its activity became progressively less as the pH fell. However, all drugs that lacked a C7 piperazine, irrespective of the nature of their substituent at this position, exhibited a progressive increase in activity as the pH was reduced. In addition it was found that, excepting cinoxacin, a urinary concentration of magnesium generally caused a further antagonism of the activity of the nine other 4-quinolone antibacterials at all pH values tested.


PMID: 3514470

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Suleiman, Z.Aliyu.; Kolawole, I.Kayode.; Ahmed, B.AbdulKadir.; Wahab, K.Wasiu., 2016: Fluoroscopic-guided supra-scapular nerve block in the management of shoulder pain in a Nigerian Teaching Hospital: Report of five cases. Shoulder pain complaints are common in our environment. The disorder can occur among the young active age group or in the older patients as a result of degenerative changes with its attendant limitations of the function of the affected upper limb,...

Brandimarte, C.; Teneggi, V.; Pescarmona, E.; Serra, P., 1987: Does Schoenlein-Henoch disease exist in the elderly? Description of a case of microangiopathic vasculitis clinically similar to Schoenlein-Henoch disease in a 71-year-old man. Recenti Progressi in Medicina 78(9): 397-401

Crusz, H., 2011: The early development of the rostellum of Cysticercus fasciolaris Rud., and the chemical nature of its hooks. Journal of Parasitology 33(2): 87-98

Iversen, B.M.; Kvam,; Svarstad, E., 1996: Treatment of hypertension in renal parenchymatous disease. Hypertension is a common finding in patients with renal parenchymatous diseases. Development of hypertension causes increased proteinuria, decline in glomerular filtration rate and reduced life span in experimental models of glomerulonephritis. Hy...

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WARD.G.E.; EDGERTON.M.T.; CHAMBERS.R.G.; McKEE.D.M., 1959: Cancer of the oral cavity and pharynx and results of treatment by means of the composite operation (in continuity with radical neck dissection). Annals of Surgery 150(2): 202-220

Rizzardini, M.; Carelli, M.; Cabello Porras, M.R.; Cantoni, L., 1994: Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine. In in vitro systems haem oxygenase-1 (HO-1) mRNA increases after exposure to agents causing oxidative stress. We lowered cellular antioxidant defence systems in vivo by giving mice increasing doses (0.15 g/kg-1.6 g/kg) of DL-buthionine-(S,R)-sulph...

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