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Effect of quinidine and tetrodotoxin on the activation of non-adrenergic nerves in guinea-pig trachealis muscle

, : Effect of quinidine and tetrodotoxin on the activation of non-adrenergic nerves in guinea-pig trachealis muscle. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology 86(1): 11-15

Activation of non-adrenergic neurones in guinea-pig trachealis muscle was accomplished by electrical field stimulation and by the neurotoxin aconitine, in the presence of atropine and propranolol. Aconitine (10(-5) M) activated non-adrenergic neurones more slowly, but was as efficacious as supramaximal field stimulation (70 V, 1 msec, 1-100 Hz), producing 70-80% of the maximal relaxation to forskolin or theophylline. Quinidine (3 X 10(-5) M-3 X 10(-4) M) and tetrodotoxin (5 X 10(-9) M-3 X 10(-6) M) blocked relaxations to aconitine and field stimulation, without affecting smooth muscle relaxant responses to forskolin. The results suggest that the non-adrenergic inhibitory effects of quinidine are related to its presynaptic local anaesthetic actions, rather than to postsynaptic receptor blockade of the non-adrenergic inhibitory neurotransmitter.


PMID: 2881704

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