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Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis

, : Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. American Journal of Emergency Medicine 10(4): 301-310

The objective of this study was to determine the effect of steroid therapy on pulmonary function, admission rates, and relapse rates in patients presenting with acute exacerbations of asthma. Computerized MEDLINE and SCIENCE CITATION searches were combined with review of reference lists from book chapters and articles to identify published randomized trials on steroid interventions. Over 700 articles were reviewed by two independent reviewers who identified 30 relevant randomized controlled trials for analysis. Study validity was independently assessed by two reviewers and information regarding populations, interventions, and outcomes was abstracted. Binary outcomes were combined and reported as odds ratios (OR), using the Mantel-Haenszel method. Individual and pooled effect sizes (ES) were determined for pulmonary function data. The authors found that the use of steroids early in the treatment of asthmatic exacerbations reduces admissions in adults (common OR 0.47; 95% confidence interval (CI) 0.27, 0.79) and children (OR 0.06-0.42). They found steroids effective in preventing relapse in the outpatient treatment of asthmatic exacerbations (OR 0.15; CI 0.05, 0.44). Oral and intravenous steroids appear to have equivalent effects on pulmonary function in acute exacerbations (ES -0.07; CI -0.39, 0.25). The authors conclude that overall, steroid therapy provides important benefits to patients presenting to emergency departments with acute exacerbations of asthma. Further research into dosage, alternative routes of administration, and alternative outcome measures is needed.


PMID: 1535500

Other references

Mirshamsi, S.; Ashford, M.L.J.; Spanswick, D., 2000: Electrophysiological heterogeneity of glucose-receptive neurones in the rat arcuate nucleus. European Journal of Neuroscience 12(Supplement 11): 158

Zahorska, D.K.cmar, S.B.okes, P., 1979: Application of ultra filters as enzymatic reactors for extracting pectins from solutions. Kvasny prumysl 25(5): 112-114

Zaher, H.; Caramaschi, U., 1996: Hydrops triangularis (triangle water snake). Herpetological Review. December; 274: 212-213

McDonald, R.B.; Herrmann, S.; Curry, D.L., 1992: Norepinephrine sensitivity of the endocrine pancreas in aging F344 rats. The effect of norepinephrine (NE) infusion on glucose-stimulated insulin secretion was evaluated in whole perfused pancreases isolated from 6-, 12-, and 26-month-old male Fischer 344 (F344) rats. Glucose-stimulated insulin secretion was significan...

Genell, S.; Ohlsson, K.; Wehlin, L., 1977: The fate of iodine 131 labeled human pancreatic elastase ec after intra duodenal administration. Human pancreatic elastase [EC-] labeled with 131I was administered into the duodenum through the fiberoptic gastro-duodenoscope in 8 persons. Radioactivity was measured in their plasma, urine and feces during 72 h. 131I was present in the...

Erséus, C.; Envall, I.; De Wit, P.; Gustavsson, L.M., 2017: Molecular data reveal a tropical freshwater origin of Naidinae (Annelida, Clitellata, Naididae). The phylogenetic relationships within Naidinae (Annelida, Clitellata, Naididae) were investigated, using six molecular markers, both mitochondrial (12S rDNA, 16S rDNA, the COI gene) and nuclear (18S rDNA, 28S rDNA, the ITS region). Thirty-seven no...

Thompson, J., 1976: Beekeeping--the economics of migration. Australasian beekeeper: 78 (4) 78-83

Jerram, David C., 1958: Stimulation of salivary secretion by a group of aliphatic amines; their mechanism of action and structure-activity relationships. Dissertation Absts 18(5): 1816

Karimi, M.Hossein.; Hejr, S.; Geramizadeh, B.; Nikeghbalian, S.; Kamali-Sarvestani, E.; Yaghobi, R., 2014: Study of the relationships between IL-23R, IL-17, IL-21 polymorphisms and serum level of IL-17, IL-21 with acute graft rejection in iranian liver transplant recipients. Cytokines are important factors determining the outcome of transplantation. Since host ability in cytokine production may be affected by cytokine genes polymorphisms, the aim of the present study was to investigate the effect of IL-17, IL-23R and...

Urbanski J., 1972: On the knowledge of balkan alopiinae mollusca pulmonata systematic zoo geographic and ecological studies on the mollusks of the balkan peninsula part 11. Bulletin de la Societe des Amis des Sciences et des Lettres de Poznan Serie D Sciences Biologiques (12-13): 251-260, 1971