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Effects of interleukins 1, 2 and 3 on follicle-stimulating hormone-induced differentiation of rat granulosa cells


, : Effects of interleukins 1, 2 and 3 on follicle-stimulating hormone-induced differentiation of rat granulosa cells. Molecular and Cellular Endocrinology 62(1): 103-111

A growing body of evidence indicates that substances released by activated immune cells can directly influence the functions of various endocrine cells. In the present study, the direct in vitro effects of interleukins (IL) 1, 2, and 3 on follicle-stimulating hormone (FSH)-stimulated steroidogenesis and luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor induction in granulosa cells were examined. In the absence of FSH, none of the interleukins stimulated steroid production or LH/hCG receptor induction during a 2-day culture period. However, in the presence of FSH, both IL-1 alpha and IL-1 beta inhibited, in a dose-dependent manner, progesterone and estrogen production as well as LH/hCG receptor induction in response to FSH. In contrast, both agents augmented 20 alpha-hydroxy-4-pregnen-3-one (20 alpha-OH-P) production stimulated by FSH. In all cases, less IL-1 beta than IL-1 alpha was required to produce a comparable effect. IL-2 slightly, but significantly, enhanced both FSH-stimulated progesterone and 20 alpha-OH-P production but had no effect on FSH-stimulated estrogen production or LH/hCG receptor induction. IL-3 potentiated the 20 alpha-OH-P response to FSH by up to 65% but had no effect on FSH-stimulated progesterone or estrogen production or LH/hCG receptor induction. These data suggest that the interleukins, which are key mediators of immune responses, may affect mechanisms crucial for the maturation and differentiation of granulosa cells and thus may also play a regulatory role in reproductive function.

US$29.90

PMID: 2501121


Other references

Mhuircheartaigh, Róisín.Ní.; Rosenorn-Lanng, D.; Wise, R.; Jbabdi, S.; Rogers, R.; Tracey, I., 2010: Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol. While ubiquitous, pharmacological manipulation of consciousness remains poorly defined and incompletely understood (Prys-Roberts, 1987). This retards anesthetic drug development, confounds interpretation of animal studies conducted under anesthesi...

Brand, TE., 1981: Presence of the parasitic gastropod Melanella townsendi in the holothurian Isostichopus fuscus. Bulletin of the American Malacological Union Incorporated, 39

Ranvir Singh, 1973: Effect of MH, TIBA and IAA on sex expression in papaya. Maleic hydrazide, 2,3,5-triiodobenzoic acid and IAA applied twice at fortnightly intervals and at fortnightly and monthly intervals until flowering, in 100, 200 and 300 p.p.m. concentrations, failed to produce any significant change in flower sex...

Obee Bruce, 1991: Probing our undersea frontier. Canadian Geographic 111(3): 64-74

Oeser R., 1975: The behavior of a rook corvus frugilegus with a beak deformity. Beitraege zur Vogelkunde 21(5): 346-348

Van-Vegten, Ja, 1982: Increasing stock numbers on deteriorating rangeland. Proceedings of the Symposium on Botswana's First Livestock Development Project and Its Future Implications Robert K Hitchcock ed: 07

Vykhodtsev, M., 1971: High yields of alfalfa. Zemledelie 11 34-36

Thomas, R., 1965: The feeding habits of captive amphisbaenids. Herpetologica, 21: 238

Morimoto S.; Fujiwara T.; Ohtsuki I., 1988: Restoration of calcium activated tension of cdta treated single skeletal muscle fibers by troponin c. Single fibers from glycerinated rabbit psoas muscle were treated with a solution containing CDTA, a strong chelator of metal ions. The CDTA-treated fibers lost all of the troponin C and showed no Ca2+-activated tension development. The addition of...

Grof, P., 1956: Contributions on the action mechanism of skin stimulation. Archiv für Klinische und Experimentelle Dermatologie 202(2): 183-198