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Effects of protein-protein and protein-lipid interactions on heme site conformation in the mitochondrial b cytochromes

, : Effects of protein-protein and protein-lipid interactions on heme site conformation in the mitochondrial b cytochromes. Journal of Biological Chemistry 261(12): 5480-5486

Removal of lipid from detergent-solubilized succinate cytochrome c reductase by a mild method leads to a series of changes in the optical and EPR spectra of the b cytochromes. This culminates in a state that resembles purified b cytochromes from the same source and bisimidazole ferriheme model complexes. Reconstitution of the lipid-depleted complex with phospholipid restores the native spectra in a significant fraction of the complexes in the early stages of lipid depletion. Once the final state has been reached, however, reconstitution has so far been incapable of restoring described in this communication can be related to a model for integral membrane cytochromes.


PMID: 3007507

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