geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of two cannabinoids upon abstinence signs in ethanol-dependent mice


, : Effects of two cannabinoids upon abstinence signs in ethanol-dependent mice. Pharmacology, Biochemistry, and Behavior 9(1): 11-15

The effects of delta9-tetrahydrocannabinol (THC) and nabilone, a synthetic cannabinoid, upon handling-induced convulsions and responsiveness to electric foot shock were examined during abstinence in ethanol-dependent mice. The severity of handling-induced convulsions was apparently increased by THC (10-40 mg/kg) and nabilone (2.5-10 mg/kg) but both drugs elicited similar convulsions in normal mice never exposed to ethanol. Enhanced responsiveness to electric foot shock, evident during abstinence, was suppressed by THC (10-40 MG/KG). The effects of ethanol upon the two abstinence signs were determined for comparative purposes. Ethanol (0.5-4 g/kg) reduced the severity of handling-induced convulsions and suppressed the increased responsiveness to electric foot shock. These results indicate that THC and nabilone have similar actions upon two abstinence signs in ethanol-dependent mice, and although one sign (responsiveness to electric foot shock) was clearly alleviated, another (handling-induced convulsions) was not.

US$29.90

PMID: 568289


Other references

Varga, A., 1979: Das Vorkommen von Vertigo substriata (Jeffreys 1833) in Ungarn. Soosiana, 7: 43-45

Durenberger, D., 1994: Managed competition. Using market incentives to control costs, quality. Minnesota Medicine 77(9): 25-26

Reithinger, R.; Ngondi, J.M.; Graves, P.M.; Hwang, J.; Getachew, A.; Jima, D.; Amena, M.; Bergeron, L.; Bilak, H.; Chirwa, B.; Demeke, F.; Dinkessa, W.; Ejigsemahu, Y.; Emerson, P.M.; Endeshaw, T.; Etana, K.; Fente, G.; Filler, S.; Frolov, A.; Gausi, K.; Gebre, T.; Gebreyesus, T.Adhanom.; Getachew, A.; Getachew, A.; Graves, P.M.; Hailegiorgis, Z.; Hailemariam, A.; Hwang, J.; Jima, D.; Kebede, H.; Lilay, A.; Lungu, C.; Medhin, A.; Mekasha, A.; Miller, J.; Mosher, A.W.; Mulatu, S.; Nefdt, R.; Ngon, 2015: Risk factors for anemia in children under 6 years of age in Ethiopia: analysis of the data from the cross-sectional Malaria IndicatorSurvey, 2007. Malaria is a leading cause of morbidity in Ethiopia. However, its transmission varies in both space and time, and large areas of the country are hypoendemic and epidemic-prone. The Ethiopia National Malaria Indicator Survey 2007 is a cross-section...

Oliver, F.J.; de la Rubia, G.; Feener, E.P.; Lee, M.E.; Loeken, M.R.; Shiba, T.; Quertermous, T.; King, G.L., 1991: Stimulation of endothelin-1 gene expression by insulin in endothelial cells. The present study characterized the regulation of the genetic expression of the vasoactive peptide endothelin-1 (ET-1) by insulin in bovine aortic endothelial cells. By RNA blot analysis, insulin (1.67 x 10(-8) M) increased ET-1 mRNA levels by 2.3...

Wojtasik, W., 1975: A comparative evaluation of effect of neuroleptoanalgesia II and morphine on clinical changes in recent myocardial infarction. Przeglad Lekarski 32(9): 702-705

Whittier, E.O.; Cary, C.A.; Ellis, N.R., 1935: The effects of lactose on growth and longevity. Feeding of a ration containing lactose to young laboratory animals caused them to grow more rapidly than others fed on a ration containing sucrose. This greater rate of growth is accounted for by increased production of muscle and bone, not in acc...

Boiziau, C.; Thuong, N.T.; Toulmé, J.J., 1992: Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides. We have demonstrated that the synthesis of cDNA by avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases can be prevented by oligonucleotides bound to the RNA template .apprxeq. 100 nucleotides remote from the 3'...

James, I., 2016: Integrated care. Fostering pride in care with the 'three Ps'. Health Service Journal 126(6480): 21-23

Cappa, S., F.; Nespor, M.; Ielasi, W.; Miozzo, A., 1997: The representation of stress: Evidence from an aphasic patient. We report the case of an aphasic patient who, following an acquired lesion involving the left temporo-parietal cortex, produced many word stress errors in spontaneous speech, naming of objects and reading aloud. The stress impairment concerned exc...

Pfurtscheller, R., 1969: Circuit arrangement to keep a stimulating current constant. Medical & Biological Engineering 7(2): 247-247