+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Evidence that 5-HT1A receptors are involved in the adrenaline-releasing effects of 8-OH-DPAT in the conscious rat

, : Evidence that 5-HT1A receptors are involved in the adrenaline-releasing effects of 8-OH-DPAT in the conscious rat. Naunyn-Schmiedeberg's Archives of Pharmacology 341(4): 381-384

8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a 5-HT1A receptor-selective agonist that has recently been reported to trigger adrenal catecholamine release and hyperglycemia. The aim of this study was to analyze in the conscious rat whether the 5-HT1A receptor subtype is involved in these effects. 8-OH-DPAT (0.1-1 mg/kg, i.v.) evoked dose-dependent increases in plasma adrenaline and glucose concentrations. Increases in plasma adrenaline levels peaked 5 min after administration of 8-OH-DPAT; in contrast, plasma glucose levels rose throughout the 20 min period of analysis. Prior administration of (-)pindolol, a beta-adrenoceptor antagonist that blocks 5-HT1A receptors, markedly diminished the rise in plasma adrenaline levels and abolished the hyperglycemia triggered by 8-OH-DPAT. On the other hand, neither the selective beta 1-adrenoceptor antagonist, betaxolol, the selective beta 2-adrenoceptor antagonist, ICI 118.551, nor the 5-HT2 receptor antagonist, ketanserin, affected 8-OH-DPAT-induced increases in plasma adrenaline levels. In addition, except for ICI 118.551 pretreatment, which delayed the hyperglycemic effect of 8-OH-DPAT, none of these antagonists affected the rise in glycaemia evoked by 8-OH-DPAT. The data suggest that the adrenaline-releasing and a major part of the hyperglycemic effects of 8-OH-DPAT are mediated by activation of 5-HT1A receptors.


PMID: 1970616

Other references

Gorsuch, R.L., 1980: Interactive models of nonmedical drug use. Nida Research Monograph 30: 18-23

Xu, Y.; Rodger, P.Mark., 2016: Improved estimation of density of states for Monte Carlo sampling via MBAR. We present a new method to calculate the density of states using the multistate Bennett acceptance ratio (MBAR) estimator. We use a combination of parallel tempering (PT) and multicanonical simulation to demonstrate the efficiency of our method in...

Catcheside, D.G., 1947: Genetic effects of radiations. A review of work on the relationship between mutation rate and radiation dosage. Methods of mutation detection are described.

Destrade C.; Jaffard R.; Cardo B., 1979: Effects of aversive appetitive or neutral brain stimulation on memory consolidation possible implication of the cholinergic septo hippocampal pathway. Acta Neurobiologiae Experimentalis (Warsaw) 39(4): 253-254

Gomez Brunet, A.; Lopez Sebastian, A.; Muniz Herrando, E.; Cabellos, B., 1992: Luteal function and LH secretion during the postpartum anoestrus in Manchega ewes. Effect of season of lambing and time of weaning. During the postpartum period, blood samples were collected from 39 ewes at intervals of 3-4 days. For ewes lambing in June and separated from their lambs for 18 h daily or once a week, or not separated, the interval from lambing to 1st ovulation a...

Kim, K.; Son, Y.; Lee, W.B.; Lee, K.S.on, 2013: Moving bed adsorption process with internal heat integration for carbon dioxide capture. A moving bed adsorption (MBA) process with heat integration is proposed as a potentially viable post-combustion process for the capture of CO<inf loc="post">2</inf> from large-scale CO<inf loc="post">2</inf...

Staiano, M.; Pennacchio, A.; Varriale, A.; Capo, A.; Majoli, A.; Capacchione, C.; D'Auria, S., 2017: Enzymes as Sensors. Over the last few decades the development of new technologies, the fabrication of new materials, and the introduction of nanotechnologies created new trends in a series of advances that produced innovations in biological sensing devices with a wid...

Collet, T-Hai.; Sonoyama, T.; Henning, E.; Keogh, J.M.; Ingram, B.; Kelway, S.; Guo, L.; Farooqi, I.Sadaf., 2017: A Metabolomic Signature of Acute Caloric Restriction. The experimental paradigm of acute caloric restriction followed by refeeding can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Metabolomics,...

Marta Moreno, J., 2004: Introduction to clinical management. The clinical management is a type of health care service management that probably will develop in the next future. It is a powerful tool that can offer a better health assistance (in its technical, economic and patient's satisfaction componen...

Shioda, G.; Sasaki, M.S., 1962: An in vitro study of the somatic chromosomes of the mink (Mustela vison).. The diploid chromosome number in cultured lung cells from a mink was 30. Chromosome morphology is described. The X-chromosome has a median or submedian centromere. It corresponds in length to autosomes nos. 9-11. The Y is the smallest chromosome....