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Fatal iron intoxication with multiple coagulation defects and degradation of factor VIII and factor XIII

, : Fatal iron intoxication with multiple coagulation defects and degradation of factor VIII and factor XIII. Scandinavian Journal of Haematology 22(3): 235-240

A severe iron intoxication in a 15-year-old girl resulted in profound damage to vital organs and multiple clotting defects, but no haemorrhagic diathesis. Investigation revealed not only impaired synthesis of coagulation factors but also abnormal proteolysis by plasmin as well as by other proteolytic enzymes liberated from leucocytes and damaged tissue cells affecting especially factor VIII and factor XIII.


PMID: 451454

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