+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

GABAergic control of rubral single unit activity during a reaction time task

, : GABAergic control of rubral single unit activity during a reaction time task. Experimental Brain Research 84(2): 285-296

The activity of 61 rubral neurones was recorded in association with microinjections of GABA, muscimol, bicuculline-methiodide or saline, in cat Red Nucleus area, during the performance of a reaction time task. The depressing action of GABA and muscimol on the firing of most neurones (17/23) suggests that, in a behavioural situation, an inhibitory GABAergic control can be exerted on rubral neurones discharging with different patterns during the reaction time task. The motor slowing down induced by GABA and muscimol is in agreement with a general reduction of the rubral output. Injections of bicuculline, whose antagonistic effects on GABA transmission are well established in the Red Nucleus, had various consequences on the firing of rubral neurones: 1) the decreases of activity related to the reaction time task were never suppressed, suggesting that these task-related inactivations are probably not mediated by GABA A receptors; 2) an enhancement of the tonic and phasic discharges was found for 1/4 of the neurones (7/29), which were either activated or not modulated in relation to the reaction time task, suggesting that a sustained GABA A-mediated inhibition, blocked by bicuculline, could be exerted on these neurones; 3) a reduction of the tonic and phasic discharges was observed for other neurones (15/29), which were either activated, inactivated or not modulated in relation to the reaction time task, suggesting that the activity of these neurones could be controlled by inhibitory processes not mediated by GABA A receptors, possibly enhanced or released by bicuculline. The delay in motor triggering induced by bicuculline could be related to the disruption of the pattern or rubral output during the reaction time task, as a result of the opposite changes affecting the firing of rubral neurones. A well-balanced GABAergic activity appears to be critical in the control of rubral firing during the performance of the reaction time task.


PMID: 2065735

Other references

Rushton, W.A.; Henry, G.H., 1968: Bleaching and regeneration of cone pigments in man. Regeneration after full bleaching is twice as fast when bleaching takes 1 sec as when it takes 2 min. This is not related to the photoreversal that may result from multiple quantum hits per molecule. It is also not related to Villermet and Weale&a...

Knoff, Carl., 1999: Is continuous forestry activity the way forward for the goshawk? Blir bestandsskogbruket honsehaukens bane?. Var Fuglefauna. Juli; 222: 81-86

Adair, Robert K., 1993: Effects of ELF magnetic fields on biological magnetite. The effects of 60 Hz magnetic fields of 5 mu-T (50 mG) or less on biological structures holding magnetite (Fe-3O-4) are shown to be much smaller than that from thermal agitation; hence such interactions cannot be expected to be biologically signif...

Jacobsen, J.S.; Refolo, L.M.; Conley, M.P.; Sambamurti, K.; Humayun, M.Z., 1987: DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide. The carcinogen aflatoxin B1 (AFB1), upon activation to a hypothesized AFB1-2,3-oxide (AFB1-oxide), reacts with DNA guanines. Aflatoxin B1-2,3-dichloride (AFB1-Cl2) was originally synthesized as an electronic analog for the putative AFB1-oxide, whi...

Glover J.E., 1975: New finds of sand fulgurites from the Perth Basin, Western Australia. Journal of the Royal Society of Western Australia 58(2): 54-58

Norris, K.A., 1998: Stable transfection of Trypanosoma cruzi epimastigotes with the trypomastigote-specific complement regulatory protein cDNA confers complement resistance. Trypanosoma cruzi blood stage trypomastigotes are highly resistant to complement-mediated killing in normal serum. A previously described trypomastigote surface glycoprotein was shown to have binding affinity for human complement components C3b an...

Cetin, B.; Atasever, T.; Akdemir, U.Ozgur.; Senturk, S.; Tufan, G.; Turan, N.; Buyukberber, S.; Coskun, U.; Benekli, M., 2014: The role of positron emission tomography with 18F-fluorodeoxyglucose in nodal staging of clinical and radiological Nā‚€ head and neck cancers. The objective of the study was to evaluate the impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) imaging on nodal staging for head and neck cancers. This was a retrospectively analyzed single institution st...

Zhao, X-gang.; Zhao, G-feng.; Ma, Y-feng.; Jiang, G-yu., 2007: Research progress in mechanism of traumatic brain injury affecting speed of fracture healing. In patients who have sustained traumatic brain injury with associated extremity fracture, there is often a clinical perception that the rate of new bone formation around the fracture site increases.(1) An overgrowth of callus is observed and ectop...

Santos, G.; Cuddihy, L.; Stone, C., 1988: Firetree control in Hawaii Volcanoes National Park. Research progress report Western Society of Weed Science: 00-101

Maquinay, C., 1964: Urology Of Childhood. Revue Medicale de Liege 19: 221-226