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Gastrin releasing peptide in human neuroendocrine tumours


, : Gastrin releasing peptide in human neuroendocrine tumours. Journal of Pathology 147(4): 237-244

Neuroendocrine tumours of the lung and gut are known to possess bombesin-like immunoreactivity. The recent observation that gastrin releasing peptide (GRP), a 27 amino acid peptide isolated from the porcine intestine, may be the mammalian analogue of bombesin led us to look for this peptide in a variety of human neoplasms. Formalin-fixed tissues from 85 tumours were examined by the immunoperoxidase technique, using specific antisera to the GRP molecule (1-27) and the GRP fragment (1-16). Intense cytoplasmic GRP immunoreactivity was seen in thyroid medullary carcinomas (3/3), carcinoids of lung, pancreas, and intestine (22/36), and paragangliomas (2/3). Less frequent staining was present in pulmonary small cell (oat cell) carcinomas (1/18) and pituitary adenomas (1/6). Complete absence of immunoreactivity was observed in three phaeochromocytomas, five Merkel cell tumours, six neuroblastomas and 15 non-neuroendocrine tumours. Normal neuroendocrine cells of the thyroid (C-cells) and bronchial mucosa (Kulchitsky cells) exhibited GRP immunoreactivity; nerve fibres from all sites failed to demonstrate staining for GRP. In each positive case, the pattern of staining for GRP (1-27) and GRP (1-16) was identical, although the GRP (1-16) immunostaining was weaker. These findings indicate that bombesin immunoreactivity in human neuroendocrine cells and tumours is attributable to GRP-like molecules and that GRP is a useful marker of neuroendocrine differentiation in many tumours.

US$19.90

PMID: 3003308

DOI: 10.1002/path.1711470402


Other references

Schwalm, J-David.R.; Ahmad, M.; Eikelboom, J.W.; Natarajan, M.K., 2010: A national survey of Canadian practice patterns of warfarin after anterior wall myocardial infarction in the current era of dual antiplatelet therapy. American Journal of Cardiology 105(12): 1844-1844

Nganga, L., 2016: Patient's death drove me to become more assertive. During my last placement in my first year of training, I was working on a cardiothoracic ward where the patients were mostly pre- and post-surgery.

Russo, C.R.; Welch, T.D.; Sangha, R.S.; Greenberg, M.L., 2016: Brugada Syndrome Presenting as Polymorphic Ventricular Tachycardia-Ventricular Fibrillation Lasting 94 Seconds Recorded on an Ambulatory Monitor. Cardiac arrhythmias are common causes of syncope. Brugada syndrome is an uncommon but serious genetic arrhythmia disorder that can be unmasked by medicines causing sodium channel blockade. This report documents a case of Brugada syndrome and polym...

Clarke, S.Z.egler, P.; Dwyer, J.; Hendricks, K., 2006: Take a look at the diets of our youngest Americans! Lessons from the Feeding Infants and Toddlers Study. Nutrition today- 41(4): 153-159

Lanzén, A.; Simachew, A.; Gessesse, A.; Chmolowska, D.; Jonassen, I.; Øvreås, L., 2014: Surprising prokaryotic and eukaryotic diversity, community structure and biogeography of Ethiopian soda lakes. Soda lakes are intriguing ecosystems harboring extremely productive microbial communities in spite of their extreme environmental conditions. This makes them valuable model systems for studying the connection between community structure and abioti...

Han, P.W., 1968: Energy metabolism of tube-fed hypophysectomized rats bearing hypothalamic lesions. American Journal of Physiology 215(6): 1343-1350

Vandenplas, O.; Malo, J.L.; Pauli, G., 1994: Non-allergenic bronchial hyperreactivity and occupational agents. The relationship between occupational asthma (OA) and non-specific bronchial responsiveness (NSBR) is reviewed. Natural or laboratory exposure to ubiquitous allergens can induce or increase NSBR. Reduction of exposure has an opposite effect. Preli...

Sepriano, A.; Rubio, R.; Ramiro, S.; Landewé, R.; van der Heijde, Désirée., 2017: Performance of the ASAS classification criteria for axial and peripheral spondyloarthritis: a systematic literature review and meta-analysis. To summarise the evidence on the performance of the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) (also imaging and clinical arm separately), peripheral (p)SpA and the enti...

Pechere, J.F., 1964: A Convenient Cell For Dialysis Of Small Samples. Analytical Biochemistry 8: 134-136

Carbonara, A.O.; Heremans, J.F., 1963: Subunits of normal and pathological gama-1A-globulins. (beta-2A-globulins). Archives of Biochemistry and Biophysics 102: 137-143