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Genotoxicity of ethyl carbamate in the Drosophila wing spot test: dependence on genotype-controlled metabolic capacity

, : Genotoxicity of ethyl carbamate in the Drosophila wing spot test: dependence on genotype-controlled metabolic capacity. Mutation Research 244(3): 201-208

Ethylcarbamate has a clear genotoxic potential in Drosophila melanogaster. In the somatic mutation and recombination test (SMART) it induces, in a dose-dependent manner, single spots as well as twin spots. The twin spots indicate a recombinogenic activity of ethyl carbamate. A strong strain difference demonstrates that the metabolic activation of ethyl carbamate to DNA binding metabolites most probably also in Drosophila involves cytochrome P450-dependent enzyme activities.


PMID: 2114542

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