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Granulocytes as effectors in cell-mediated cytotoxicity of adherent target cells


, : Granulocytes as effectors in cell-mediated cytotoxicity of adherent target cells. Cancer Research 35(8): 2169-2176

In the microassay for cell-mediated immunity, detachment of adherent target cells from the wells occurs to an even greater extent when tested with granulocytes than when tested with lymphocytes. Intact cells are not necessary since the sonic extract from granulocytes causes the same effect. The reaction by granulocytes appears to be mediated by enzymes, and is inhibited by the presence in the wells of hyaluronic acid. Moreover, it is limited to the detachment of adherent target cells, since neither intact nor sonically disrupted granulocytes exhibit cytotoxic activity in the chromium release assay. The detachment of target cells is also inhibited by heparin which may be used to specifically mullify the effect of granulocytes contaminating lymphocyte suspensions.

US$29.90

PMID: 1149032


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Lin, Y-Zeng.; Yao, M-Yin.; Liu, M-Hua.; Peng, Q-Mei.; Zhang, X.; Chen, T-Bing.; Xu, Y., 2014: Determination of parameter range in detecting Cu of Gannan navel orange by LIBS setup. In order to improve the precision and sensitivity of laser-induced breakdown spectroscopy device on detecting heavy metal, parameter optimization should be done. After selecting the initial delay time parameter in detecting navel orange experiment...

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Malik K.U.; Muscholl E., 1967: The action of sympathomimetic amines on the sympathetic response in the perfused mesenteric artery preparation of the rat. Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie 257(3): 311-312

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