geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Growth-associated changes in fatty acid compositions of nuclear phospholipids of liver cells


, : Growth-associated changes in fatty acid compositions of nuclear phospholipids of liver cells. Biochimica et Biophysica Acta 1084(1): 53-59

To know the possible relationships between nuclear phospholipids and cell proliferation, we have extensively analyzed phospholipids extracted from the nuclei of rat hepatic cells at various growth states. The content of phospholipid in nuclei as well as its composition was similar among liver cells tested, i.e., the regenerating rat livers (28 h, post-hepatectomy), sham-operated or non-treated control livers, and rat ascites hepatoma, AH7974 cells. In contrast, the fatty acid compositions of phospholipids differed from each other among these cells. At the 2-position of phospholipids in the regenerating liver nuclei at 28 h after partial hepatectomy, 18:1 (oleic acid) increased transiently at the expense of 20:4 (arachidonic acid) and 22:6 (docosahexaenoic acid), compared with those in the sham-operated control nuclei. This change in fatty acid composition was commonly observed throughout all phospholipids analyzed, i.e., phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and phosphatidylserine (PS). On the other hand, the change at 1-position was rather limited: in the regenerating liver nuclei (28 h), 18:1 increased only in PC at the expense of 18:0 (stearic acid). The similar and more marked deviation at the 2-position was observed with AH7974 nuclei it contained approximately 2-times more of 18:1 in PC, PE and PI than regenerating liver nuclei (28 h), and the decreased levels of 20:4 and/or 22:6. It should be noted that there were significant differences in the fatty acid compositions of PE and PS between sham-operated and non-treated controls. So, the sham-operated rat is the appropriate control for proliferation.

US$29.90

PMID: 2054377


Other references

Onillon, B.; Nelson, C.J., 1994: Mineral nitrogen assimilation in tall fescue Localization and effect of nitrogen rate. Plant Physiology (Rockville) 105(1 SUPPL ): 61

Palmas, C.; Bortoletti, G.; Conchedda, M.; Contini, C.; Gabriele, F.; Ecca, A.R., 2001: Study on immunobiology in ectoparasites of public health interest: Rhipicephalus sanguineus. The recently defined range of Mediterranean Spotted Fever (MSF) in Sardinia coincides with that of the widely studied Rickettsia conorii vector, the brown dog tick Rhipicephalus sanguineus. This tick is major vector of disease in humans, domestic...

Fredskild Bent, 1985: Holocene pollen records from West Greenland. Pages 643-681 1985

McKay, S.; Bromhaar, M.M.; de Jongste, J.C.; Hoogsteden, H.C.; Saxena, P.R.; Sharma, H.S., 2001: Pro-inflammatory cytokines induce c-fos expression followed by IL-6 release in human airway smooth muscle cells. Background: Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. Aims: To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells....

Zhang, Y.; Zhang, C.; Zhai, H., 2017: Solitary Osteogenic Sternum Plasmacytoma on Bone Scintigraphy and FDG PET/CT. We reported a rare solitary osteogenic sternum plasmacytoma case. A 49-year-old woman experienced progressing pain in the sternum for 2 years. Abnormal Tc-MDP accumulation and increase in F-FDG uptake (SUVmax, 4.4) were co-localized with the osteo...

Dockray, G.J., 1982: The physiology of cholecystokinin in brain and gut. British Medical Bulletin 38(3): 253-258

D.R.cco, F.; Szathmari, A.; Mottolese, C., 2016: Wire fixation of internal distractor for cranial vault remodeling. Posterior cranial vault distraction osteogenesis is currently used to enlarge the cranial volume and control the intracranial pressure. This procedure carries the risk of hardware dislocation, and especially in infants, as their skull being thin,...

Romero Alvarez H., 1971: Participation of the community in the promotion of environmental improvement. Salud Publica de Mexico 13(4): 513-516

Veldink, J.G.; Van Riemsdijk, J.F., 1949: The importance of having sheep on the farm. THE ratio between sheep and cattle in the Netherlands has shown considerable variation at different periods. In Dec. 1881-1890 the ratio was 1 sheep to 1.9 cattle; in Dec. 1940 the corresponding ratio was 1 sheep to 7.8 cattle, and in Dec. 1946 1...

Kodroń, A.; Ghanim, M.; Krawczyk, K.K.; Stelmaszczyk-Emmel, A.; Tońska, K.; Demkow, U.; Bartnik, E., 2017: Mitochondrial DNA in pediatric leukemia patients. Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic l...