+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hyperbaric oxygen and multiple sclerosis: final results of a placebo-controlled, double-blind trial

, : Hyperbaric oxygen and multiple sclerosis: final results of a placebo-controlled, double-blind trial. Journal of Neurology, Neurosurgery, and Psychiatry 50(11): 1402-1406

The long term results are reported of a trial involving 120 patients with chronic multiple sclerosis who were randomised to receive either 100% oxygen at 2 atmospheres absolute (ATA) for 90 minutes daily for 20 sessions or placebo therapy with air using a simulated compression procedure. The previous finding of subjective improvement in bowel/bladder function at the end of treatment was not confirmed by objective urodynamic assessment. The treatment did not alter disease progression as measured by the Kurtzke disability status scale nor did it alter the rate of acute relapse. There was less deterioration in cerebellar function at one year in the treated patients as measured by the Kurtzke functional systems scale. No other differences were found between the two groups. Psychometric tests and measurements of lymphocyte sub-populations showed no treatment related effects. Evoked potential studies showed no improvements but there was a significant reduction in amplitude of the visual evoked potential in the treated patients at the end of therapy. This might indicate a reversible degree of retinal damage induced by oxygen toxicity.


PMID: 3320274

Other references

Perrigot, M., 1977: Neurological control of micturition. A study of the literature is reported on the subject of the control centres in the brain and medulla of the bladder reflex and their central and peripheral connections. Reference is made to the modes of action, from a pharmacological and physiolog...

Macedo, H.; Bigal, M.; Bordini, C.; Speciali, J., 2003: Temporomandibular joint dysfunction in migraine and chronic migraine; a controlled study. Cephalalgia 23(7): 583-584, September

Mikhaĭlov, M.L., 1975: Influence of angiotensin II on the fatty acid level in the triacylglycerides of the blood plasma of rabbits. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia: 75-77

Byers, R.E., 2003: Flower and fruit thinning and vegetative: fruiting balance. The history of flower and fruit thinning, along with the commercially important physiological effects of thinning are discussed. Adjuvants and thinning chemicals and their physiological effects, as well as their applications are presented. The inf...

Varshney, G.K.; Palmer, R.H., 2006: The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut. During embryonic development the midgut visceral muscle is formed by fusion of cells within the visceral mesoderm, a process initiated by the specification of a specialised cell type, the founder cell, within this tissue. Activation of the recept...

Margerit, D.; Kraimps, J.L.; Richer, J.P.; Carretier, M.; Barbier, J., 1994: Follow-up of elderly patients previously treated for uncomplicated acute lithiasic cholecystitis. Surgery is usually indicated in elderly patients with acute lithiasic cholecystitis although single antibiotics are often used for patients over 75 with complex medical histories and major visceral lesions. In our series of 45 patients, no new bil...

Anonymous, 2006: Texas' Green City. A roundup of attractions, activities, stores, restaurants, and accommodation in Austin, Texas, that are of interest to gardeners.

García-Arpa, Mónica.; Rodríguez-Vázquez, Mía.; Cortina-de la Calle, P.; Romero-Aguilera, G.; López-Pérez, R., 2005: Multiple and familial eccrine angiomatous hamartoma. Acta Dermato-Venereologica 85(4): 355-357

Brooke, M.M.; Norman, L.; Allain, D.; Gorman, G.W., 1957: Isolation of Trypanosoma cruzi-like organisms from wild animals collected in Georgia. Journal of Parasitology, 43: 15

White S.H.; King G.I., 1985: Molecular packing and area compressibility of lipid bilayers. Knowledge of the molecular packing of lipids and water in lipid bilayers is important for understanding bilayer mechanics and thermodynamics. Information on packing is most often obtained from X-ray or neutron diffraction measurements. Given the d...