+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunologic and anti-immunosuppressive effects of vitamin A

, : Immunologic and anti-immunosuppressive effects of vitamin A. Pharmacology 30(4): 181-187

The effects of vitamin A alcohol on cell-mediated immunity in vitro and its ability to prevent the immunosuppressive effects of prednisolone and cyclophosphamide in vivo were studied in mice. Lymphocytes from Calmette-Guérin bacillus (BCG) sensitized mice were stimulated specifically with purified protein derivative (PPD) and nonspecifically with phytohemagglutinin (PHA). In the vitamin A injected animals there was significant enhancement of the spleen lymphocyte transformation not only in the PPD-sensitive cells but also in the T cells at large. In addition, vitamin A was able to restore to normal the cellular and humoral forms of immunity in prednisolone and cyclophosphamide-treated animals. It is suggested that vitamin A in nontoxic doses may have a role in enhancing the responses to weak immunogens and in reversing immunosuppression.


PMID: 3991796

Other references

Przyborski, J.M.; Bartels, K.; Lanzer, M.; Andrews, K.T., 2003: The histone H4 gene of Plasmodium falciparum is developmentally transcribed in asexual parasites. Histones are abundant nuclear core proteins that are present in all eukararyotes and are responsible for linking chromosomes and packaging them into tight chromatin aggregates. The histone H2A, H2B, and H3 genes and a partial sequence of the histo...

Ragab, H.A.; Samuel, S., 1955: Human infection with Linguatula in Egypt; first case recorded. Journal of the Egyptian Medical Association 38(4): 229-231

Gobeil, R.E., 1966: Notes on certain summer birds on Grand Manan. Maine Field Naturalist, 22: 87-93

Taler, I.; Phillip, M.; Lebenthal, Y.; de Vries, L.; Shamir, R.; Shalitin, S., 2013: Growth and metabolic control in patients with type 1 diabetes and celiac disease: a longitudinal observational case-control study. The occurrence of celiac disease (CD) in patients with type 1 diabetes (T1D) is increasing.To determine the effect of CD on growth and glycemic control in patients with T1D, and the effects of adherence to gluten-free diet (GFD) on these parameter...

Twersky, M.; Pasternak, D.; Borovic, I.; Malach, Y.D., 1978: Irrigation of processing tomatoes with brackish water. Brackish and fresh water was used to irrigate plants of 7 tomato cvs grown for processing. Plants watered with brackish water had a slower initial growth rate and flowered 10 days later than those watered with fresh water. Yields were reduced by 2...

Lindberg D., 1981: Some practical points concerning psycho therapy in the integrated treatment program during the 1st 3 months in a hospital comments on the 3 detailed descriptions of psycho therapy with schizophrenics. Some previous studies of individual and group psychotherapy in schizophrenia are presented. A team consisting of a main therapist (usually a specially trained psychologist or social-worker), who works closely with a group leader (usually a special...

Katashima, M.; Yamada, Y.; Yamamoto, K.; Kotaki, H.; Sato, H.; Sawada, Y.; Iga, T., 1999: Analysis of antiplatelet effect of ticlopidine in humans: Modeling based on irreversible inhibition of platelet precursors in bone marrow. The relationship between plasma concentration of ticlopidine and its inhibitory effect on platelet aggregation in human was analyzed using a pharmacokinetic/pharmacodynamic (PK/PD) model. The data of plasma concentration and inhibitory effect on p...

Burke, D.W.; Wilson, V.E.; Zaumeyer, J., 1969: Royal red, a virus-resistant Kidney Bean for production in the Northwest. Data on yield variations are presented with recommendations on production methods of this curly top virus and to the original and N.Y. No. 15 strs. of bean common mosaic virus.

Mas-Oliva, J.; Pérez-Montfort, R.; Cárdenas-García, M.; Rivas-Duro, M., 1991: Altered coupling states between calcium transport and (Ca2+, Mg2+)-ATPase in the AS-30D ascites hepatocarcinoma plasma membrane. Plasma membrane fractions from normal, regenerating liver and the AS-30D ascites hepatocarcinoma exhibited a high degree of enrichment when a set of plasma membrane enzyme markers were studied in comparison to the ones associated to the mitochondr...

Hung, C-Nung.; Mar, K.; Chang, H-Chen.; Chiang, Y-Lun.; Hu, H-Yun.; Lai, C-Chi.; Chu, R-Min.; Ma, C.M., 2011: A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration. In this study, several in vivo and in vitro comparisons were performed to test the possibility of using adipose-derived stem cells (ADSCs), a more convenient cell source than dental pulp stem cells (DPSCs), in tooth regeneration. Using an efficien...