geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship


, : Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship. International Clinical Psychopharmacology 7(1): 3-12

A dimensional relationship between central serotonergic (5-HT) system function and indices of suicidal and impulsive aggressive behaviors has been suggested by more than a decade of research in patients with psychiatric disorders. This paper reviews a series of studies conducted in healthy male individuals and in male patients with major mood and/or personality disorder involving pharmacochallenge and neurochemical strategies designed to explore the role of central 5-HT system function in the regulation of suicidal and impulsive aggressive behavior in humans. The results of these studies suggest that reduced overall central 5-HT function in the limbic-hypothalamic system is associated with suicidal and/or impulsive aggressive behaviors in patients with major mood and/or personality disorders and that diminished 5-HT post-synaptic receptor function in this brain region may be an important biological correlate of these behaviors.

US$29.90

PMID: 1624755


Other references

Gruer, L.; Cameron, J.; Elliott, L., 1993: Building a city wide service for exchanging needles and syringes. How best can injecting drug misusers obtain clean injecting equipment in a city where drug injecting is widespread? An exchange service for needles and syringes throughout Glasgow has been established in health centres and clinics in the evening....

Terrill T.R.; Conner D.L., 1982: The influence of testing environment on general and specific combining ability estimates for diverse tobaccos nicotiana. Virginia Journal of Science 33(3): 90

Turkensteen, L.J.; Mulder, A., 1996: Storage diseases of potatoes. Part 1: dry rots. Dry rot diseases of stored potatoes are distinguished from wet rots and other diseases of potato tissues and peel. The pathogens causing dry rots are divided into 3 groups: those causing early infection via the leaves (Phytophthora infestans and A...

Anonymous, 2001: 2001 Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics. Orlando, Florida, USA. March 6-10, 2001. Abstracts. Clinical Pharmacology and Therapeutics 69(2): P1-128

Steinkohl K.; Heissenhuber A.; Steinhauser H., 1990: Limitations significance and development of organic farming. Bayerisches Landwirtschaftliches Jahrbuch 67(5): 513-530

Rickma, N., 1952: Climate and tuberculosis. Strahlentherapie 88(3-4): 412-418

Keltner, A.; Marshall, W.L., 1976: Attribution and subject control factors in experimental de sensitization. Subjects' [human] recognition of the agent of change (attribution) in desensitization was manipulated by the administration of a supposedly effective (actually inert) drug. Spider phobic subjects (32) were allocated to 1 of 4 treatments: dese...

Zelent, A.; Chen, Z.; Wang, Z.Y.; Licht, J.; Waxman, S.; Strutt, P.; Reid, A., 1996: Rearrangement between PLZF and RAR-alpha genes in acute promyelocytic leukaemia. British Journal of Haematology 93(SUPPL 2): 228

Gonzalez Donoso J.M.; Linares D.; Rodriguez P.; Serrano F., 1978: Origin of globorotalia margaritae. G. margaritae Bolli and Bermudez, which is usually thought to derive from the group of G. scitula Brady, shows an ambiguous transition within the G. dalii Perconig-G. mediterranea Catalano and Sprovieri group. G. margaritae Bolli and Bermudez may...

Ahsan, F.; Arnold, J.J.; Meezan, E.; Pillion, D.J., 2003: Sucrose cocoate, a component of cosmetic preparations, enhances nasal and ocular peptide absorption. Sucrose cocoate (SL-40), an emulsifier employed in emollient, skin-moisturizing cosmetic formulations, contains a mixture of sucrose esters of coconut fatty acids in aqueous ethanol solution. In order to determine its potential utility in enhancin...