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Influence of standard and nicotine-reduced cigarette smoke on plasma concentrations of isosorbide dinitrate and its metabolites in rats

, : Influence of standard and nicotine-reduced cigarette smoke on plasma concentrations of isosorbide dinitrate and its metabolites in rats. Journal of Pharmacy and Pharmacology 43(11): 811-812

Rats dosed orally with isosorbide dinitrate (1 mg kg-1) were exposed to smoke from standard and nicotine-reduced cigarettes for 8 min using a smoking machine. Plasma concentrations of isosorbide dinitrate and 5-isosorbide mononitrate, one of its major metabolites were approximately equal in the exposed groups, but were lower than in the non-smoking control group. The 2-isosorbide mononitrate concentration was also lower in the group exposed to smoke from standard cigarettes. Since the pharmacokinetics were influenced by smoke from both types of cigarette smoke, the effect may be attributed in large part to non-nicotine components of the smoke.


PMID: 1686914

Other references

Timm, M.; Klie, H.; Richter, H.; Perlberg, K.W., 1996: A method for specific isolation of verotoxin-producing Escherichia coli colonies. The described colony immunoblot is a special double membrane-agar technology, which permits the specific isolation of VTEC in biological materials decided VT-positive by EIA or PCR. The produced Verotoxin (VT) is detected on the surface of the low...

Zoorabadi, M.; Indraratna, B.; Nemcik, J., 2012: A new equation for the equivalent hydraulic conductivity of rock mass around a tunnel. International Journal of Rock Mechanics and Mining Sciences (1997) 54

Traurig, M.T.; Permana, P.A.; Nair, S.; Kobes, S.; Bogardus, C.; Baier, L.J., 2006: Differential expression of matrix metalloproteinase 3 (MMP3) in preadipocytes/stromal vascular cells from nonobese nondiabetic versus obese nondiabetic Pima Indians. Prior microarray studies comparing global gene expression patterns in preadipocytes/stromal vascular cells isolated from nonobese nondiabetic versus obese nondiabetic Pima Indians showed that matrix metalloproteinase 9 (MMP9) is upregulated in obe...

Krotoszyner, M., 1904: Determination of Functional Capacity of Kidneys, Special Reference to Kidney Surgery. California State Journal of Medicine 2(8): 255-259

Grzanka, D.; Domaniewski, J.; Grzanka, A., 2005: Effect of doxorubicin on actin reorganization in Chinese hamster ovary cells. Exposure of Chinese hamster ovary (CHO AA8) cells to doxorubicin in doses of 75 muM resulted in reorganization of F-actin filaments and characteristic feature of apoptosis. Even increase in size of CHOAA8 cells was observed. Attached cells become...

Murri, L.; Bonuccelli, U.; Muratorio, A.; Saggese, G.; Biava, G.; Bottone, E., 1979: Circadian rhythm in gonadotropin secretion in children with constitutional stature delay. Plasma levels of luteinizing and follicle-stimulating hormones were measured for 24 hours in six subjects affected by constitutional stature delay associated with sexual maturation delay. The children in pubertal stage exhibited fluctuating plasma...

Coradini A.; Gavrishin A.I.; Cerroni P.; Forni O., 1991: G-mode classification of Martian IR data. Pages 272 1991

Boguslawski, W., 1970: Selection method in the prevention of Peronospora destructor on seed Onion. Experiments on seed onion in 4 fields during 1962-63 showed the importance of selection in the control of P. destructor . Frequency of selection should be greater where there is higher primary infection and more rapid development of the disease.

Whitehead, V.M.; Cooper, B.A.; Pratt, R.F., 1972: Absorption of folic acid. Lancet 1(7745): 326-326

Gandolfo, R.L., 1971: Role of expectancy, amnesia, and hypnotic induction in the performance of posthypnotic behavior. Journal of Abnormal Psychology 77(3): 324-328