geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Inhibition by dietary benzylselenocyanate of hepatocarcinogenesis induced by azoxymethane in Fischer 344 rats


, : Inhibition by dietary benzylselenocyanate of hepatocarcinogenesis induced by azoxymethane in Fischer 344 rats. Japanese Journal of Cancer Research 80(10): 952-957

The effect of dietary benzylselenocyanate (BSC), a novel organoselenium compound and its sulfur analog, benzylthiocyanate (BTC), on hepatocarcinogenesis induced by azoxymethane (AOM) was investigated in male F344 rats. Eighty-one weanling rats were divided into 3 groups and were raised on a semipurified diet (control diet). Starting from 5 weeks of age, groups of animals consuming the control diet were fed one of the experimental diets containing 25 ppm BSC or BTC. An additional group was continued on the control diet. At 7 weeks of age, animals were given weekly sc injections of AOM (15 mg/kg body weight once weekly for 2 weeks). One week after the second AOM injection, those groups receiving BSC and BTC diets were transferred to the control diet and continued on this diet until termination of the experiment at 34 weeks after the last AOM injection. For quantitative analysis of enzyme-altered liver cell foci, glutathione S-transferase placental form was stained by an immunohistochemical technique. The results indicate that the incidence and the density of the enzyme-altered foci were significantly lower in AOM-treated rats fed the diet containing 25 ppm BSC (foci incidence 56%, foci density 2.43/cm2) than in AOM-treated animals fed the control diet (foci incidence 92%, foci density 4.79/cm2). The incidence of small altered foci was significantly inhibited in rats fed the BTC diet (35%) as compared to those fed the control diet (68%), but the degree of inhibition was more pronounced in animals fed the BSC diet than in those fed the BTC diet.

US$29.90

PMID: 2515179


Other references

Newman, J.E., 1995: Bonding amalgams. Journal of the American Dental Association 126(7): 824-826

Bonn, W.G., 1978: Fire blight bacteria in dormant apple and pear buds. To determine whether viable and pathogenic Erwinia amylovora bacteria overwinter in dormant bud tissue, buds from orchards with a history of fire blight were assayed during Dec., Feb. and Apr. for 3 seasons. E. amylovora was detected in only 2 sym...

Silfverberg, H., 1985: Order Coleoptera (beetles). Suborder Polyphaga. Chrysomeloidea. Chrysomelidae. Unknown

Kuzmenkov, A.I.; Vassilevski, A.A., 2017: Labelled animal toxins as selective molecular markers of ion channels: applications in neurobiology and beyond. Animal toxins are traditional and indispensible molecular tools that find application in different fields of biochemistry, neurobiology and pharmacology. These compounds possess several outstanding properties such as high affinity and selectivity...

Burda, D., 2005: Doc-execs wielding power. Modern Healthcare 35(31): 32-33

Yan, B.; Chen, L., 2013: Coincidence probability of precipitation for the middle route of South-to-North water transfer project in China. The coincidence of precipitation for an inter-basin water transfer project may determine the feasibility of the project and whether there is enough water to be diverted. The degree of coincidence statistically depends upon the spatial dependence o...

Haimson B.C., 1977: Stress measurements using the hydrofracturing technique. Pages 233-246 1977

Kirpichenko A.A.; Pashkov A.A., 1986: Neurophysiological analysis of disorders of the functional activity of projective cerebral systems in neurotic patients. To study the neurophysiological mechanisms of neurasthenia, hysterical neurosis and obsession neurosis with a view to the practical employment of the results, the authors examined 100 patients and 40 normal subjects using the method of evoked pote...

Kenmore, P., 2007: Mergers. Executive expectations. Health Service Journal 117(6065): 28-29

Sedrak, A.; Rao, S.P.; Miller, S.T.; Hekmat, V.; Rao, M., 2009: A prospective appraisal of pulmonary hypertension in children with sickle cell disease. Pulmonary hypertension (PHT) is a life-threatening complication of sickle cell disease that occurs in 20% to 40% of adults. Measurement of maximal tricuspid regurgitant jet velocity (TRV) by echocardiography provides a noninvasive screening tool;...