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Insulin-dependent diabetes, an autoimmune disease

, : Insulin-dependent diabetes, an autoimmune disease. Comptes Rendus de L'academie des Sciences. Serie Iii, Sciences de la Vie 303(8): 299-301

In type I (insulin-dependent) diabetes evidence for an autoimmune process is now fully established. This is also true for a similar disease observed in the NOD mouse and the BB rat. In addition to circulating antipancreatic antibodies, we demonstrated T-lymphocyte mediated cellular immunity in both these diabetic animals and in the human. Immunological abnormalities precede the development of diabetes and may be responsible for beta cell alteration. Evidence for this interpretation appears stronger for cell-mediated than for humoral immunity. However, full demonstration and understanding of the relationship between anti-beta cell immunity and beta cell alteration still raise many unresolved problems.


PMID: 3094847

Other references

Han, M.-Jung; Jung, K.-Hong; Yi, G.; Lee, D.-Yeon; An, G., 2007: Rice Immature Pollen 1 (RIP1) is a regulator of late pollen development (vol 47, pg 1457, 2006). Plant and Cell Physiology 48(1): 204

Okada, M.; Morimoto, Y.; Sugimoto, T., 2002: Early diagnosis and therapy of deep venous thrombosis with 111 indium labeled platelets. Clinical assessment of platelet scintigraphy by using autologous platelet labeled with 111-indium oxine to detect thrombotic activity for deep vein thrombosis. Platelet accumulation on scintigrams had a tendency to correlate with aggravation of ac...

Marton, K.; Kovi, Z.; Egri, Tímea., 2017: Is interference control in children with specific language impairment similar to that of children with autistic spectrum disorder?. The purpose of the study was to examine resistance to proactive interference, which is strongly associated with working memory (WM) performance and language processing, in children with specific language impairment (SLI), with autism spectrum diso...

Akimov A.P.; Genshaft Y.S., 1990: Eruptive breccia of alkali-ultrabasic composition in the Lesser Caucasus. Doklady Akademii Nauk SSSR 313(5): 1182-1184

Sederholm Jakob Johannes, 1913: Different types of pre-Cambrian unconformities. Report of the

Finkielstein, C.; Cymeryng, C.; Paz, C.; Neuman, I.; Dada, L.; Cornejo Maciel, F.; Mele, P.G.; Mendez, C.F.; Maloberti, P.; Solano, A.R.; Schimmer, B.P.; Podestá, E.J., 1996: Characterization of the cDNA corresponding to a phosphoprotein (p43) intermediary in the action of ACTH. We have previously isolated and partially-sequenced a soluble phosphoprotein (p43) that acts as intermediary in the stimulation of steroid synthesis. In this report we have used synthetic peptides whose sequences match those obtained from p43 to g...

Anonymous, 2015: Oral Abstract Session: Young Investigator Award Competition 4. European Journal of Preventive Cardiology 22(1 Suppl): S161-S162

Kleerekoper, H.; Grenier, F., 1952: The bottom sediments of lake Lauzon, Montcalm County, province Quebec. I. Chemical and physical investigations. The surface sediments were found to consist of a 3.5 to 350 mm. thick sludge layer of primarily organic nature and they were underlain by a layer of sandy organic detritus. Analysis of core samples gave average values in percentage dry weight of:...

Arensburg, L.; Wilderjans, H.; Simon, O.; Dewulf, J.; Boussauw, B., 2012: Nonseptic tenosynovitis of the digital flexor tendon sheath caused by longitudinal tears in the digital flexor tendons: a retrospective study of 135 tenoscopic procedures. Longitudinal tears (LTs) of the digital flexor tendons are an important cause of chronic tenosynovitis of the digital flexor tendon sheath (DFTS). The origin of those marginal tears is not yet fully understood. The long-term outcome after medical...

Simroth, H., 1910: Quelques remarques sur la locomotion des Gasteropodes. Bulletin de la Societe Zoologique Paris, 35 10-14