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Interactions of La3+ with phosphatidylserine vesicles. Binding, phase transition, leakage and fusion


, : Interactions of La3+ with phosphatidylserine vesicles. Binding, phase transition, leakage and fusion. Biochimica et Biophysica Acta 558(3): 338-343

The interaction of La3+ with phosphatidylserine vesicles is elucidated by binding studies, differential scanning calorimetry, X-ray diffraction, freeze fracture electron microscopy, and release of vesicle contents. La3+ effectively competes with Ca2+ for phosphatidylserine binding sites. The saturation level is close to a La/lipid ratio of 1:3. A concentration of 0.1 mM of La3+ is sufficient to induce fusion between sonicated vesicles.

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PMID: 508753


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