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Intracoronary nifedipine--separation of drug specific and vehicle-induced effects


, : Intracoronary nifedipine--separation of drug specific and vehicle-induced effects. Zeitschrift für Kardiologie 75(11): 682-687

In 22 patients we studied the effects of 0.2 mg nifedipine given intracoronary during the course of routine PTCA. In 9 patients the effect of the nifedipine-free solvent was additionally tested. Injections were made through the guiding catheters or balloon catheters as pre- and poststenotic injections. We monitored frequency and character of pain, ECG changes (continuous recording of full 12-lead ECG) and pressure recordings from the left ventricle and pre- and poststenotic coronary artery. Short-lasting "stinging" pain sensations were described by 41% of the patients after nifedipine and 33% after solvent injection (n.s.). Patients described the pain as different from their usual angina pectoris. Pain was more frequent after poststenotic injections (through the balloon catheter) than after pre-stenotic injections (59% vs. 19%, p less than 0.01). ECG changes were peaking T waves, ST elevation and ST depression. They were recorded after pre-stenotic injections in 21 of 22 cases for nifedipine and 6 of 9 for solvent and after poststenotic injections in 22 of 22 cases for nifedipine and 8 of 9 cases for solvent. After nifedipine 0.2 mg i.c. the pressures decreased by 3.5% pre-stenotic and 9.7% post-stenotic. LVEDP increased by 10.7%. Our results show that pain sensations and electrocardiographic changes occur with similar character and frequency after i.c. injections of nifedipine or nifedipine-free solvent. Thus these effects do not seem to be caused by nifedipine. Hemodynamic effects were small and there was no disproportionate decrease of poststenotic pressure.

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PMID: 2949443


Other references

Anonymous, 1973: Handbook on meat inspection. This 4th edition of a very practical pocket-sized handbook largely follows the general lay-out of earlier editions, with careful revision throughout. The closing pages summarize the legislation of the European Economic Community. Changes relevant...

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Buchko, M.; Kuzik, K.; Moravs'-Kii, B., 1977: New commercial lines of Large Wh. Visnyk sil's'kohospodars'koi nauki: (10) 39-43

Peterson, C.D., 1990: Monitoring specific variables in drug therapy. American Journal of Hospital Pharmacy 47(7): 1530-1530

Zhelnov, V.V.; Golshmid, M.V.; Simonov, V.I.; Cherkasova, N.A., 1994: Damage of cardiac conduction system in patients with Charcot-Marie disease. Kardiologiya 34(7-8): 93-94

Safianova, T.E., 1954: Results of a study of the reaction of Black Sea fishes to electric light ,. Trudy Vsesoiusnovo N I Inst Rybnovo Khoziaistva I Okeanografii: 5-187

Lehr, E.; Hohl, D.; Huber, M.; Brown, D., 2004: Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. Human papillomavirus (HPV) does not induce lysis of infected keratinocytes, and the exact mechanisms of viral escape are not known. As keratinocytes differentiate, the cornified cell envelope (CCE) develops, providing a protective barrier to the h...

Sabljic A., 1984: Predictions of the nature and strength of soil sorption of organic pollutants by molecular topology. This study was undertaken to find a simple and accurate structural parameter for the prediction of the soil sorption coefficients (Kom) of organic pollutants and to help resolve controversy about the mechanism of soil sorption. The methods used we...

Kwong, M.B., 1984: Paediatric CAPD in Hong Kong. Xianggang Hu Li Za Zhi. Hong Kong Nursing Journal: 22-24

Havlickova, H., 1972: Verifying the feeding of Sitona lineatus under field conditions by laboratory tests. The feeding of the weevil on two varieties of lentil and on one variety of Vicia leganiana at the 2-4 leaf stages of development was investigated. In all cases maximum feeding occurred on the Vicia variety. At the two-leaf stage, the weevil prefer...