geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Intravenous administration of lidocaine and amiodarone in patients with acute myocardial infarction


, : Intravenous administration of lidocaine and amiodarone in patients with acute myocardial infarction. Giornale Italiano di Cardiologia 15(3): 285-289

Lidocaine (L) in still considered the drug of choice in the treatment of life threatening ventricular arrhythmias in the setting of acute myocardial infarction (A.M.I.): this is mainly due to its proved efficacy and high therapeutic index. Since however L has well defined electrophysiologic properties (class 1 B) and does not seem to be effective in all of these patients we compared its antiarrhythmic efficacy with the one of amiodarone (A), an antiarrhythmic agent provided of electrophysiologic properties quite different from L (class 4) and usually well tolerated. Twenty-five consecutive patients with A.M.I. without haemodynamic consequences, were randomly assigned to L (bolus of 1 mg/kg followed by an infusion of 10 mg/min for 20 minutes and thereafter of 1,5 mg/min) or A (bolus of 5 mg/kg and an eventual repeat dose of 150 mg followed by an infusion of 1,8 g/24 h) The baseline arrhythmia was classified as Lown class 2 ore more in all the patients. The ventricular arrhythmias were completely relieved in 47% of the patients assigned to L and in 60% of those treated with A (p = N.S.); a minor efficacy was found in 40% of the patients of both groups; in two cases ventricular fibrillation occurred after the acute infusion of L. The antiarrhythmic effectiveness kept fit with both drugs over a 24 hours period. A prolongation of QTc interval was found to occur both after the bolus and 24 hours of treatment with A. In addition A provoked a slight decrease of systolic blood pressure. No important side effects were observed with both drugs regimens.

US$29.90

PMID: 4018467


Other references

Albizati L.D.; Walsh D.A., 1971: Characterization of phosphorylase b kinase from intestinal smooth muscle. Pharmacologist 13(2): 315

Shim, Y-Hee.; Park, H-Jung.; Choi, M.Sun.; Kim, J.Sun.; Kim, H.; Kim, J.Jae.; Jang, J-June.; Yu, E., 2003: Hypermethylation of the p16 gene and lack of p16 expression in hepatoblastoma. Hepatoblastoma is the most frequent pediatric liver tumor that develops mostly in young children. Abnormal regulation of cell cycle regulatory genes including p16 has been described, displaying no p16 mRNA and p16 protein in hepatoblastomas. The i...

Cotter, A.; Greene, R.; Turner, M., 2000: What do Irish women know about cervical screening?. In anticipation of the launch of the national cervical screening programme, a questionnaire was distributed amongst 200 women on the maternity wards of the Coombe Women's Hospital. The questionnaires revealed that 24% of the women surveyed ne...

Castro, C.-O.V.lverde, R., V., 1985: Chamaejasmin, a biflavanone from wood of Diphysa robinioides. The biflavanone chamaejasmin has been isolated from the wood of Diphysa robinioides and its structure established by the spectral data of the biflavanone and its hexaacetyl derivative.

Boldyrev, A.A.; Johnson, P., 2007: Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease. Homocysteine (HC) and its derivatives may be involved in the etiology of Alzheimer's Disease (AD), although the precise mechanisms by which these Compounds could cause cellular pathology are still unclear. Because interactions of HC with glut...

Aksel' E.M.; Dvoirin V.V.; Militosyan N.A.; Suveizde R.B., 1989: Probability of developing malignant neoplasms in the population of the latvian ssr ussr. Voprosy Onkologii (St Petersburg) 35(11): 1294-1300

Keller, D.M.; Zeng, S.X.; Lu, H., 2003: Interaction of p53 with cellular proteins. Cellular proteins that interact with p53 play a major role in both positive and negative regulation of this tumor suppressor and can fine-tune its response to specific cellular stresses. As a consequence, p53 biology will not be complete until the...

Nord, C.E.; Kager, L., 1983: Tinidazole -- microbiology, pharmacology and efficacy in anaerobic infections. The microbiological and pharmacological properties of tinidazole and its therapeutic efficacy, particularly against anaerobic infections, are reviewed. Its spectrum of activity encompasses trichomonad vaginitis, amoebiasis and giardiasis.

Gause, K.T.; Wheatley, A.K.; Cui, J.; Yan, Y.; Kent, S.J.; Caruso, F., 2017: Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery. Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advances in i...

Verrier G.; Castello Branco F., 1972: The Quenguela-north Tertiary trough and oil field; Cuanza Basin. Cretaceous and Tertiary deposits with massive salt deposit, salt tectonics, structures, oil field in Angola.