+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Involvement of catecholaminergic neurones and alpha-adrenoceptors in the wet-dog shake and forepaw licking behaviour produced by the intrathecal injection of an analogue of thyrotrophin-releasing hormone (CG 3509)

, : Involvement of catecholaminergic neurones and alpha-adrenoceptors in the wet-dog shake and forepaw licking behaviour produced by the intrathecal injection of an analogue of thyrotrophin-releasing hormone (CG 3509). Neuropharmacology 26(8): 1147-1155

Intrathecal injection of the analogue of TRH, CG 3509, into conscious rats produced dose-related wet-dog shakes and forepaw licking, which showed a bell-shaped relationship of intensity to dose. Pretreatment with alpha-MPT intraperitoneally, markedly reduced levels of noradrenaline and dopamine in the spinal cord and brainstem and attenuated both CG 3509-induced responses, while intrathecal treatment with DSP4 selectively reduced noradrenaline in the spinal cord without affecting either behaviour. Since denervation supersensitivity may develop following treatment with DSP4, these results are not inconsistent with a proposal that bulbospinal noradrenergic neurones modulate the behaviour induced by CG 3509. Wet-dog shakes and forepaw licking induced by CG 3509 were reduced by pretreatment with phenoxybenzamine or prazosin, suggesting that a tonic noradrenergic pathway may facilitate both behavioural responses through alpha 1-adrenoceptors. Methoxamine, combined with CG 3509 partially attenuated the wet dog shake behaviour, but methoxamine produced marked hindlimb jerking which might physiologically antagonise wet-dog shakes. Concomitant administration of clonidine and CG 3509 potently reduced wet-dog shakes in a dose-related manner but did not significantly affect forepaw licking, while idazoxan did not significantly affect either response. The latter findings imply that alpha 2-adrenoceptors play different roles in modulating the two behavioural responses and the possible synaptic location of the receptors is discussed. Taken together these results suggest that CG 3509 may release noradrenaline from bulbospinal neurones regulating motor function.


PMID: 2889164

Other references

Lebeau, F.J.; Sosa, O.M.; Fumagalli, A., 1956: The striped rust in Guatemala during 1956. The wheat varieties Mentana, Kenya Farmer, Chapingo 53, Lerma 52 and Kentana 54B and the cross Supremo x Kenya x Mida have proved highly resistant to Puccinia glumarum in Guatemala in 1956.

Gutierrez-Correa, J.; Hod, M.; Passoneau, J.V.; Freinkel, N., 1991: Glycogen and enzymes of glycogen metabolism in rat embryos and fetal organs. Glycogen content and the enzymes of glycogen metabolism have been measured in the postimplantation rat embryo over a period ranging from 9.5 to 18.5 days of gestation. The earliest periods studied were at days 9.5 and 10.5 of gestation, when the y...

Lukjan, Z., 1987: Absenteeism due to diseases of the respiratory tract and smoking in the textile industry. Pneumonologia Polska 55(7-8): 370-372

Perret, B.Cker, L.Cos, E., 1955: Late results of 23 lobotomies. Toulouse Medical 56(5): 283-289

Kotaiah, P., 1996: Potential, problems and perspectives of rural industrialisation. An examination of the issues surrounding rural industrialization in developing countries is presented within the concluding address of the First Asia-Pacific Symposium on Rural Industrialization, held in Colombo, Sri Lanka, in July 1996. It focuse...

Hecker, J.; Prokopenko, D.; Lange, C.; Fier, H.Loehlein., 2017: PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies. To quantify polygenic effects, i.e. undetected genetic effects, in large-scale association studies, we propose a generalized estimating equation (GEE) based estimation framework. We develop a marginal model for single-variant association test stat...

Beresford, M.J.; Fitzsimons, J.T., 1992: Intracerebroventricular angiotensin II-induced thirst and sodium appetite in rat are blocked by the AT1 receptor antagonist, Losartan (DuP 753), but not by the AT2 antagonist, CGP 42112B. In the rat, intakes of water and 1.8% NaCl induced by I.C.V. angiotensin II were inhibited by prior I.C.V. injection of the angiotensin subtype 1 receptor antagonist, Losartan, but not by the subtype 2 receptor antagonist, CGP 42112B. Drinking ind...

Stallknecht, Helmut., 1996: The joy of aquariums Aquarium discussions for beginners and the advanced Freude an Aquarien Aquaristische Plaudereien fur Anfanger und Fortgeschrittene. Unknown

Narishige, T.; Egashira, K.; Akatsuka, Y.; Katsuda, Y.; Numaguchi, K.; Sakata, M.; Takeshita, A., 1993: Glibenclamide, a putative ATP-sensitive potassium channel blocker, inhibits coronary autoregulation in anesthetized dogs. We tested the hypothesis that ATP-sensitive K+ channels are involved in the mechanism mediating coronary autoregulation in open-chest dogs. We perfused the left anterior descending coronary artery with arterial blood from an extracorporeal circuit...

Ruimy, R.; Dos-Santos, M.; Raskine, L.; Bert, Fédéric.; Masson, Ré.; Elbaz, S.; Bonnal, C.; Lucet, J-Christophe.; Lefort, Aès.; Fantin, B.; Wolff, M.; Hornstein, M.; Andremont, A., 2008: Accuracy and potential usefulness of triplex real-time PCR for improving antibiotic treatment of patients with blood cultures showing clustered gram-positive cocci on direct smears. Bacterial identification and antibiotic susceptibility testing currently require 48 h when a first blood culture (BC) is positive for clustered gram-positive cocci on direct smear examination (DSE). Meanwhile, antibiotic treatment is often inadequ...