+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Iron metabolism and anaemia in pregnancy

, : Iron metabolism and anaemia in pregnancy. Clinics in Haematology 14(3): 613-628

The mechanism by which anaemia develops in pregnancy is well understood: haemodilution causes a fall in the haemoglobin concentration during the first and second trimesters of normal pregnancies. Negative iron balance throughout pregnancy, particularly in the latter half, may lead to iron deficiency anaemia during the third trimester. The increase in iron demand is required to meet the expansion in maternal haemoglobin mass and to meet the needs of fetal growth. Fetal demand for iron results in a unidirectional flow of iron to the fetus against a concentration gradient regulated by fetal requirements for iron; this iron transfer occurs almost entirely irrespective of maternal iron status. The development of maternal iron deficiency during pregnancy may be detected by monitoring the haemoglobin concentration frequently; values falling to less than 11 g/dl should be regarded as abnormal, but specific red cell changes, such as microcytosis, may be lacking. A diagnosis of iron deficiency can be most conveniently confirmed by the serum ferritin concentration falling to less than 12 micrograms/l. Women at risk from iron deficiency anaemia can therefore be readily identified and corrective treatment instituted prior to the development of severe anaemia. A serum ferritin concentration of less than 50 micrograms/l in early pregnancy is an indication for iron supplements. Women in whom the serum ferritin concentration is greater than 80 micrograms/l at booking are unlikely to require iron supplements during pregnancy. This approach would eliminate the need for routine prophylactic iron therapy, which, in populations enjoying a good nutritional status, can no longer be justified in early pregnancy. Furthermore, any risk to the fetus from severe maternal anaemia would be avoided by prophylaxis and prompt treatment.


PMID: 3907911

Other references

Macnamarra, D., 1959: Ultrasonic therapy; severe frostbite case. Physical Therapy Review 39(3): 160-161

Jaroslaw Czubinski, Krzystof Dwiecki, Aleksander Siger, Eleonora Lampart-Szczapa, Malgorzata Nogala-Kalucka, 2012: Interactions between Lupinus angustifolius seeds lipoxygenase and native phenolic compounds in the model system. The aim of this study was to investigate the activity of lipoxygenase extracted from <i>Lupinus angustifolius</i> seeds and its interactions with native lupin polyphenols. The examinated enzyme is active at pH 7.5 causing peroxidation...

George R.A.; George G.P.; Herr J.M.Jr, 1988: A quantitative analysis of female gametophyte development in field and greenhouse grown plants of glycine max and phaseolus aureus papilionaceae. A statistical analysis of size for the megasporocyte, functional megaspore, and 2-,4-,8-nucleate, and mature female gametophytes for Glycine max and Phaseolus aureus grown in the field and greenhouse was accomplished from measurements of the lengt...

Jaramillo A.E., 1988: Growth of douglas fir in southwestern oregon usa after removal of competing vegetation. U S Forest Service Research Note PNW (470): 1-10

Wojcikowski, C.; Szlabowicz, D., 1977: Binding of sulfonyl urea derivatives to bovine serum albumin part 1 binding of spc 703 n p toluene sulfonyl 5 methyl 2 pyrazoline 1 carboxamide tolbutamide glibornuride and glipizide. Four labeled sulfonyled sulfonylureas, 14C-SPC-703 [N-(p-toluenesulfonyl)-5-methyl-2-pyrozoline-1-carboxamide], 35S-tolbutamide, 3H-glibornuride and 14C-glipizide were investigated for binding to bovine serum albumin (BSA). BSA has 2 different sit...

Chelimsky, G.; Gerrek, M.; Boseman, L.; Arden, S.; Hupertz, V.; Czinn, S., 2000: Are serologic/clinical tests predictors of inflammatory bowel disease ?. JPGN 31(Supplement 2): S17

Anonymous, 1980: 60th birthday of TS.E. Mirtskhulava. Gidrotekhnika i melioratsiia: (7) 38

Anonymous, 1966: The hygienic production of watercress: summary of a report by the watercress working party of the Public Health Laboratory Service. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 25: 146-151

Navar Chaidez, J.J. de; Contreras Avina, J., 2000: Fitting the Weibull distribution to diameter structures of uneven-aged pine stands in Durango, Mexico. The Weibull distribution has become a classic tool in forest management for the estimation and projection of diameter structures. This report presents a summary of six methods to estimate the parameters used in the Weibull distribution, to test th...

Onishi, S.; Miyaji, T., 1973: On the effect of validamycin in rats and mice. Medical Journal of Osaka University 23(4): 215-227