+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities

, : Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences of the United States of America 83(16): 5894-5898

A cDNA sequence coding for a human interleukin has been isolated from a concanavalin A-activated human T-cell cDNA library based on homology with a mouse interleukin cDNA that expresses B-cell stimulatory factor 1 (BSF-1) activity and T-cell- and mast-cell-stimulating activities. The human cDNA contains a single open reading frame encoding a protein of 153 amino acid residues including a putative signal peptide. Amino acid sequences of the mouse and human polypeptides, deduced from their cDNAs, share extensive homology with the exception of about 40 amino acid residues near the middle portion, which share little homology. Supernatant of COS-7 monkey cells transfected with the human cDNA clone stimulated proliferation of human helper T-cell clones and of anti-IgM-activated human B cells, two properties of mouse BSF-1 on mouse cells. These results indicate that this human cDNA clone encodes a protein structurally and functionally homologous to mouse BSF-1.


PMID: 3016727

Other references

Lovat R.P.; Zamel G.I.; Zenari L.P., 1993: TBM use in mine development. Publication Series - Australasian Institute of Mining and Metallurgy 6/93: 75-82

Nunes, C.; Taylor, B.M., 2016: Modelling the time to detection of urban tuberculosis in two big cities in Portugal: a spatial survival analysis. Portuguese National Tuberculosis Control Programme. To examine delays in tuberculosis (TB) diagnosis using a spatial component in two high-incidence cities, Lisbon and Oporto, in Portugal, a low-incidence country. A retrospective nationwide study...

Cheema, S.; Uppal, H., 1980: Anti-transpirants. Annual reviews of plant sciencesub 1980) 1(1): 115-140

Anonymous, 2001: Stress over 54-hour week. NlmCategory="UNASSIGNED">THE HIGH COURT in London is hearing the case of a nurse who claims her life became unbearable because of the excessive workload she faced.

Reddy, N.; Ramaiah, K.; Reddy, K.; Rao, K., 1983: Nitrate and nitrite reduction as influenced by S-(4-chlorobenzyl)-N, N-diethyl thiocarbamate in two tropical weed species. Proceedings: Plant sciences Indian Academy of Sciences 92(5): 393-396

Roemisch, J.; Feussner, A.; Stoehr, H.A., 1999: The F VII-activator A new player in haemostasis?. Blood 94(10 SUPPL 1 PART 2): 92b, Nov 15

Kris, M.G.; Millward, M., 1999: Docetaxel (Taxotere) in the treatment of non-small cell lung cancer. Seminars in Oncology 26(3 Suppl 10): 1-2

Furuya, Y.; Kagaya, T.; Nishizawa, Y.; Ogura, H., 1998: Differential effects of the strychnine-insensitive glycine site antagonist (+)-HA-966 on the hyperactivity and the disruption of prepulse inhibition induced by phencyclidine in rats. The amplitude of the acoustic startle response is reduced by a preceding weak stimulation which by itself does not elicit the startle response. This phenomenon is named prepulse inhibition (PPI) and is thought to reflect the operation of the senso...

Jaskolski S., 1933: Les gisements argento-stanniferes de Potosi en Bolivie (Zloza srebrowocynowe Potosi w Boliwji). Rock, minerals, and genesis of the tinsilver deposit of Potosi, Bolivia.

Johnson, B.L.; Kilmann, P.R., 1975: Locus of control and perceived confidence in problem-solving abilities. Journal of Clinical Psychology 31(1): 54-55