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Kinetics of insulin disappearance from plasma in cortisone-treated normal subjects

, : Kinetics of insulin disappearance from plasma in cortisone-treated normal subjects. Clinical Endocrinology 26(5): 623-628

The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of steady state plasma insulin concentrations; normoglycaemia was preserved by a glucose clamp technique. The experimentally determined data were compared using a previously validated model of saturation kinetics. The amount of glucose required to maintain normoglycaemia during the insulin infusions was significantly less in the cortisone study than in the control study, while the parameter estimates for the kinetics of insulin disappearance from plasma were unaffected by cortisone. Thus, insulin action and insulin kinetics in the steady state are dissociated in normal subjects rendered insulin resistant by short-term cortisone treatment.


PMID: 3311480

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Belloin, J.C., 1988: Milk and dairy products: production and processing costs. This paper reviews basic concepts of cost accounting and suggests methods for calculating and managing the costs of producing, processing and marketing milk and milk products. Topics covered include: estimation and control of prices; milk producti...

Pogodina, V.V.; Koreshkova, G.V., 1977: Interspecies interactions of arboviruses part 2 participation of the genomes of 2 flaviviruses west nile encephalitis and japanese encephalitis in formation of a virus clone with dual antigenic determinants. A peculiar clone, 41/WN+JE+, possessing antigenic determinants of 2 flaviviruses, West Nile (WN) and Japanese encephalitis (JE), is described. The antigenic duality of this clone exceeded the cross reactions between WN and JE viruses; either antis...

Poenaru, S., 1966: Hypoglycemia in treated diabetes mellitus in children. Studii Si Cercetari de Endocrinologie 17(3): 269-276

Lambe Lawrence Morris, 1917: On Cheneosaurus tolmanensis, a new genus and species of trachodont dinosaur from the Edmonton Cretaceous of Alberta. Ottawa Naturalist Pages 117-123

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Leandoer, L.; Appelgren, L.; Bergentz, S.E., 1969: Fibrinogen turnover after massive haemorrhage in heparinized dogs. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 1(2): 115-125

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