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Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine


, : Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine. Journal of Clinical Investigation 89(6): 1885-1891

The oxidative modification of low density lipoprotein (LDL) may play an important role in atherosclerosis. We found that the antioxidant N,N'-diphenyl-1,4-phenylenediamine (DPPD) inhibits in vitro LDL oxidation at concentrations much lower than other reported antioxidants. To test whether DPPD could prevent atherosclerosis, New Zealand White rabbits were fed either a diet containing 0.5% cholesterol and 10% corn oil (control group) or the same diet also containing 1% DPPD (DPPD-fed group) for 10 wk. Plasma total cholesterol levels were not different between the two groups, but DPPD feeding increased the levels of triglyceride (73%, P = 0.007) and HDL cholesterol (26%, P = 0.045). Lipoproteins from DPPD-fed rabbits contained DPPD and were much more resistant to oxidation than control lipoproteins. After 10 wk, the DPPD-fed animals had less severe atherosclerosis than did the control animals: thoracic aorta lesion area was decreased by 71% (P = 0.0007), and aortic cholesterol content was decreased by 51% (P = 0.007). Although DPPD cannot be given to humans because it is a mutagen, our results indicate that orally active antioxidants can have antiatherosclerotic activity. This strongly supports the theory that oxidized LDL plays an important role in the pathogenesis of atherosclerosis.

US$19.90

PMID: 1601995

DOI: 10.1172/JCI115793


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Lewis David R.; Scott Kevin M.; Tucker David S., 2006: Long-runout debris avalanche in Rainbow Creek at Mount Baker, Washington. Mount Baker, 50 km east of Bellingham, WA is one of the youngest stratovolcanoes in the Cascade Range. The modern cone began its activity ca. 50,000 years ago on the terranes of several older eruptive centers, one of which erupted the lava that no...

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Flot F.; Canton P.; Chassagne J.F.; Meley M.; Brice M., 1981: Problems due to dog bites on the face. Annales Medicales de Nancy et de l'Est 20(APR): 453-455

Yaegashi, T.; Endoh, N.; Uyeno, K.; Ohara Nemoto, Y.; Kimura, S., 2001: Distribution of periodontopathic microorganisms in inflamed gingival tissues from periodontitis patients. Specific Gram-negative anaerobic microorganisms have been implicated in human periodontitis. The periodontopathogens colonize in the gingival crevice with various mechanisms including fimbriae (FimA), and are thought to invade in gingival tissues....

Stohl, W.; Mayer, L., 1987: Inhibition of T cell-dependent human B cell proliferation and B cell differentiation by polyspecific monomeric IgG. A commercially available polyspecific, monomeric IgG preparation suitable for intravenous administration (IgSRK; Sandoglobulin) can inhibit pokeweed mitogen (PWM)-induced proliferation of peripheral blood mononuclear cells (PBMC) by a small, but s...