+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lymphoblastic lymphoma in adolescents and adults. Clinical, pathological and prognostic evaluation

, : Lymphoblastic lymphoma in adolescents and adults. Clinical, pathological and prognostic evaluation. European Journal of Cancer & Clinical Oncology 22(12): 1503-1510

Sixty-four adult patients with lymphoblasts lymphoma (LB) identified according to Kiel Classification were analyzed retrospectively. Three distinct clinical presentations were identified: prevalent abdominal disease (29 pts = 45.3%), prevalent mediastinal disease (14 pts = 21.9%) and prevalent superficial node involvement (21 pts = 32.8%). On histological grounds, the patients with abdominal disease were mainly associated to "Burkitt like" cell lymphoma (55%); patients with mediastinal disease to convoluted cell type (58%); and those with superficial node disease to unclassified cell type (48%). Immunological studies showed a significant correlation between mediastinal disease and T phenotype (P = 0.0011), abdominal disease and B phenotype (P = 0.00042), and between superficial node disease and non-B non-T phenotype (P = 0.00024). Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025). Furthermore the response to therapy was strongly correlated with prognosis (P less than 0.0001) with 34.5 months median survival for complete responders, 9 months for partial responders, and 3 months for non-responders. Four patients underwent bone marrow transplantation (three autologous and one allogeneic BMT in a patient in leukemic phase); three of them are still in CR (18, 22, and 27 months from the transplant) while one patient had an early relapse and died 3 months later.


PMID: 3496223

Other references

de Padua Bertelli, A., 1977: Giant cell lesion and fibrous osseous dysplasia of the jawbones in primary hyperparathyroidism. International Surgery 62(4): 215-216

Anonymous, 2006: Better stent for leg artery blockages. Health News 12(10): 13-13

Blair, J.A., 1958: Isolation of isoxanthopterin from human urine. isoXanthopterin was isolated from human urine. 2-Amino-4-hydroxypteridine-6-carboxylic acid could not be isolated from freshly voided human urine. A scheme for the catabolism of pteroyl-L-glutamic acid is suggested.

Heyder, N.; Lutz, H.; Lux, G., 1983: Ultrasound diagnosis via the gastroscope. Eighty patients presenting with various diseases of the upper abdominal organs were investigated in an initial series of examinations performed with an ultrasonic endoscope provided with a mechanical sector scanner (7.5 MHz rated frequency, sector...

Barella, A.V.go, J., 1974: Nature of the measurement of worsted wool hairiness by means of the Barella and Viaplana electronic hairiness meter. Investigacion e informacion textil y de tensioactivos: 0, 17 (3) 319-333

Parmala, M.E., 1954: Septicaemia caused by Salmonella dublin; report of a case. Annales Medicinae Internae Fenniae 43(4): 256-263

Hoffmann, H.; Steinhauser, H., 1991: Economic aspects of sunflower cultivation in Germany. Sunflowers have only recently become an important crop in West Germany. The 1990 area under production is estimated at 24 000 ha and production at 80 000t of sunflower seed. As total production was above the quantity with an EC guarantee, the Germ...

Conroy, C.W.; Sturzenberger, O.P., 1968: The rate of calculus formation in adults. Journal of Periodontology 39(3): 142-144

Lynch, P.M., 2000: Clinical challenges in management of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer. Cancer 86(11 Suppl): 2533-2539

Januś, D.; Wójcik, M.; Drabik, G.; Wyrobek, Ł.; Starzyk, J.B., 2017: Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development. The prevalence of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) is rising in children and adolescents, and the coincidence of AIT and PTC is as high as 6.3-43%. To investigate the ultrasound manifestation of AIT in relation to...