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Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus

, : Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. Journal of Clinical Investigation 55(6): 1254-1258

57% of sera from 124 relatives of 28 patients with systemic lupus erythematosus (SLE) were found to have antibody directed against lymphocytes. The incidence in 60 members of 16 control families was 3%. Both consanguineous and nonconsanguineous relatives had the antibody in their sera. 68% of close household contacts of the SLE patients showed lymphocytotoxic antibody whereas only 23% of consanguineous relatives who had no household contact with the probands had this antibody. These data suggest that environmental factors may be important in the pathogenesis of SLE.


PMID: 1133171

DOI: 10.1172/JCI108044

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