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Malignant histiocytosis in childhood. Clinical features and therapeutic results by combination chemotherapy


, : Malignant histiocytosis in childhood. Clinical features and therapeutic results by combination chemotherapy. American Journal of Pediatric Hematology/Oncology 8(4): 300-307

Ten children, four males and six females, with malignant histiocytosis were treated from July 1980 to July 1984. None of them had an affected sibling with a similar disorder. Septic-type fever, hepatosplenomegaly, lymphadenopathy, pulmonary infiltration, and disseminated intravascular coagulation were common signs and symptoms, and convulsion occurred in four cases. The diagnosis was made from bone marrow smears in all cases. In five cases, biopsy or autopsy specimens confirmed the diagnosis. In five cases studied, proliferating histiocytes in lymph nodes were demonstrated to be S100 protein-positive. All patients were treated with adriamycin, cyclophosphamide, vincristine, and prednisone (ACOP). Complete response was achieved in four patients after two to three courses of ACOP, and another case attained complete remission after further drug treatment. The five complete responders are now alive without evidence of disease after 23-48 months from the onset. Among partial and no responders, four died within 3 months and one has been alive with disease for 2 months. Bone marrow aspiration is useful for prompt diagnosis, and early treatment with intensive combination chemotherapy improves the prognosis of malignant histiocytosis in childhood.

US$29.90

PMID: 3799930


Other references

Partida Busch, V., 2002: The demographic determinants of the aging of the population. The extent to which changes in the major demographic variables have caused the aging of the population of Mexico is analyzed. These factors include the decline in mortality since 1950, the increase in international migration since 1950, and the de...

Zacharova A.I. (Zakharova A.I.; Starovoit O.E. (Starovoyt O.Y.); Chepkunas L.S., 1978: Seismic moment and its determination in practice of data generalization of unified system of seismic observations (USSO) of the U.S.S.R. Tectonophysics: -4, Pages 247-253. 1978.

Lawson, D.M., 1971: Role of cations in the milk-ejecting action of oxytocin in rat mammary tissue in vitro. Incubation of small pieces of Ca-free rat mammary tissue in a medium containing 0-0.92mM Ca and <1 mU oxytocin/ml showed that increases in the Ca concn. caused decreases in the time taken for tissue to respond to oxytocin (latency period); at c...

Clark, A.M.; Haykowsky, M.; Kryworuchko, J.; MacClure, T.; Scott, J.; DesMeules, M.; Luo, W.; Liang, Y.; McAlister, F.A., 2010: A meta-analysis of randomized control trials of home-based secondary prevention programs for coronary artery disease. A variety of different types of secondary prevention programs for coronary heart disease (CHD) exist. Home-based programs have become more common and may be more accessible or preferable to some patients. This review compared the benefits and cost...

Golden, M.R.; Brewer, D.D.; Kurth, A.; Holmes, K.K.; Handsfield, H.Hunter., 2004: Importance of sex partner HIV status in HIV risk assessment among men who have sex with men. Clinical HIV risk assessments have not typically integrated questions about sex partners' HIV status with questions about condom use and type of sex. Since 2001, we have asked all men who have sex with men (MSM) evaluated in an urban sexually...

Braibanti, T.; Bertaccini, G.; Uva, F., 1968: "Caerulein" in the clinical radiological study of the biliary tract. Annali di Radiologia Diagnostica 41(6): 516-532

Hughes, D.A., 1968: Factors controlling emergence of pink shrimp (Penaeus duorarum) from the substrate. Biological Bulletin Marine Biological Laboratory Woods Hole, 134: 48-59

Pavel, I.; Campeanu, S., 1958: Biliary dyskinesia in relation to new diagnostic methods. Minerva Medica 49(33): 1557-1562

Fujita, K.; Morimoto, Y.; Endoh, S.; Uchida, K.; Fukui, H.; Ogami, A.; Tanaka, I.; Horie, M.; Yoshida, Y.; Iwahashi, H.; Nakanishi, J., 2010: Identification of potential biomarkers from gene expression profiles in rat lungs intratracheally instilled with C(60) fullerenes. The use of C(60) fullerenes is expected to increase in various industrial fields. Little is known about the potential toxicological mechanism of action of water-soluble C(60) fullerenes. In our previous research, gene expression profiling of the r...

Cox, R.; Bouzekri, N.; Martin, S.; Southam, L.; Hugill, A.; Golamaully, M.; Cooper, R.; Adeyemo, A.; Soubrier, F.; Ward, R.; Lathrop, G.Mark.; Matsuda, F.; Farrall, M., 2002: Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides. Circulating angiotensin-1-converting enzyme (ACE) is a highly heritable trait, and a major component of the genetic variance maps to the region of the ACE gene. The strong effect of the locus, and the interest in ACE as a candidate gene for cardio...