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Microembolism in experimental septic shock. Distribution of platelets and fibrinogen after intravenous injection of disintegrated Pseudomonas bacteria to dogs


, : Microembolism in experimental septic shock. Distribution of platelets and fibrinogen after intravenous injection of disintegrated Pseudomonas bacteria to dogs. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 9(1): 34-47

Platelets were labelled with 51Cr, fibrinogen with 125I and erythrocytes with 59Fe. Disintegrated Pseudomonas bacteria were injected intravenously and radioactive measurements were made on whole blood; tissue biopsies and clottable fibrinogen. After the infection there was an immediate but transient increase of 51Cr activity in the lung concomitant with a decrease in platelet count and 51Cr activity of blood. In the liver there was a less pronounced increase of 51Cr activity. The fibrinogen concentration decreased slightly, paralleled by the 125I activity of whole blood and of clottable fibrinogen, whereas the 125I activity in the lung and liver remained fairly constant. There was no changes of 51Cr activity or 125I activity in biopsies from muscle, pancreas, small intestine, kidney or spleen. During the experiment (3h) there were no signs of significant disseminated intravascular coagulation other than platelet aggregation. A consumption of fibrinogen related to the formation of fibrin plugs could not be detected. After injection of disintegrated Pseudomonas bacteria reversible platelet aggregates were formed and temporarily trapped in the pulmonary microcirculation. This microembolism might induce tissue damage and could be of importance for the development of septic pulmonary complication.

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PMID: 844464


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Pak, K.P.; Stepanets, I.T.; Veredchenko, Yu. P., 1966: Soil-hydrogeological investigations in the Sarpinsk lowland hi connexion with rice cultivation. When rice was grown for two years on a liman (depression) soil whose water-table lay at a depth of 5-6.5 m in very saline, sandy-loamy layers of chocolate clay, the necessary flooding produced a perched water-table above the clay. Alkalinity due t...

Schnell, D.; Kouatchet, A.T.; Lécuyer, H.; Talbi, A.; Descamps, P.; Nassif, X.; Zahar, J-R., 2010: Is extended-spectrum beta-lactamase-producing Escherichia coli rectal carriage at hospital admission predictable? Risk factors at hospital admission. Journal of Hospital Infection 76(2): 178-180

Runnells, R.R.; Powell, G.L., 1991: Managing infection control, hazards communication, and infectious waste disposal. Dentistry entered a new era in the 1980s when the development of the AIDS crisis targeted dental facilities as one source of potential cross-infection with pathogenic microorganisms. As governmental agencies "discovered" dentistry, regul...

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Gerlach, J.J.; Cope, D.A., 1963: An anomaly of the intrapetrous portion of the facial nerve. Bulletin of the School of Medicine 48: 27-28

Søholm, L.M.; Bonde, C.T.; Balleby, L.; Meisner, S., 1999: Stricture of the colon induced by hyperthermia--in connection with irrigation via sigmoidostomy. A case of thermal injury following the introduction of excessively hot tap water into the colon during irrigation of a sigmoid colostomy is described. The radiological proof of a subsequently developed colon stricture made it necessary to remove t...

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Kato, D-Ichiro.; Teruya, K.; Yoshida, H.; Takeo, M.; Negoro, S.; Ohta, H., 2007: New application of firefly luciferase--it can catalyze the enantioselective thioester formation of 2-arylpropanoic acid. We introduce a new application of firefly luciferase (EC 1.13.12.7). The firefly luciferases belong to a large superfamily that includes rat liver long-chain acyl-CoA synthetase (LACS1). LACS1 is the enzyme that is involved in the deracemization p...

Sun, Y.; Zhou, G-Qun.; Qi, Z-Yu.; Zhang, L.; Huang, S-Min.; Liu, L-Zhi.; Li, L.; Lin, A-Hua.; Ma, J., 2014: Radiation-induced temporal lobe injury after intensity modulated radiotherapy in nasopharyngeal carcinoma patients: a dose-volume-outcome analysis. To identify the radiation volume effect and significant dosimetric parameters for temporal lobe injury (TLI) and determine the radiation dose tolerance of the temporal lobe (TL) in nasopharyngeal carcinoma (NPC) patients treated with intensity mod...

Lindquist S.; Schmidt H.; Korfmann G.; Martin H.; Sanders C.; Normark S., 1990: Characterization of amp c beta lactamase noninducible mutants. Abstracts of the Annual Meeting of the American Society for Microbiology 90: 186